TY - CHAP
T1 - Object Novelty Memory Tests
T2 - Methods, Test Procedures and Measurements
AU - Paes, Dean
AU - van Hagen, Britt T.J.
AU - Prickaerts, Jos
N1 - Funding Information:
Dean Paes is financially supported by Alzheimer Nederland (grant number WE.03-2016-07) and Britt van Hagen is financially supported by the Human Enhancement and Learning (HEaL) initiative of Maastricht University.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The most commonly used rodent recognition memory tests are based on the novelty-preference paradigm. These tests are derived from the object novelty recognition (ORT) and the object location (OLT) tests. Most of these rodent recognition memory tests have been easily adopted and implemented through manipulations of the test context; number of trials and test phases and the choice of objects, their number and locations. Hence, it has been possible to assess different types of memory (spatial, nonspatial, temporal order and episodic) and processes (short-term, long-term and consolidation) within a single novelty-preference paradigm. The ORT and subsequent variants of this test contributed significantly to our understanding of the neural basis of different forms of memory. In the present chapter, the general principles of ORT and OLT, and the novel variants of these tests are described; they are followed by some considerations and discussions of the test procedures and methodologies.
AB - The most commonly used rodent recognition memory tests are based on the novelty-preference paradigm. These tests are derived from the object novelty recognition (ORT) and the object location (OLT) tests. Most of these rodent recognition memory tests have been easily adopted and implemented through manipulations of the test context; number of trials and test phases and the choice of objects, their number and locations. Hence, it has been possible to assess different types of memory (spatial, nonspatial, temporal order and episodic) and processes (short-term, long-term and consolidation) within a single novelty-preference paradigm. The ORT and subsequent variants of this test contributed significantly to our understanding of the neural basis of different forms of memory. In the present chapter, the general principles of ORT and OLT, and the novel variants of these tests are described; they are followed by some considerations and discussions of the test procedures and methodologies.
KW - Associative recognition memory
KW - Object in context test
KW - Object in place test
KW - Object location recognition test
KW - Object novelty recognition test
KW - Object pattern separation
KW - Object temporal order recognition
U2 - 10.1016/B978-0-12-812012-5.00003-3
DO - 10.1016/B978-0-12-812012-5.00003-3
M3 - Chapter
VL - 27
T3 - Handbook of Behavioral Neuroscience
SP - 39
EP - 51
BT - Handbook of Object Novelty Recognition
A2 - Ennaceur, Abdel
A2 - De Souza Silva, Maria Angelica
PB - Elsevier
ER -