Abstract
Accumulating evidence suggests that obesity is a major risk factor for the initiation, progression, and outcomes of coronavirus disease 2019 (COVID-19). The European Association for the Study of Obesity (EASO), as a scientific and medical society dedicated to the promotion of health and well-being, is greatly concerned about the concomitant obesity and COVID-19 pandemics and their impact on health and society at large. In this perspective, we will address the inherent immunological perturbations and alterations in the renin-angiotensin-aldosterone system in patients with obesity and COVID-19, and discuss how these impairments may underlie the increased susceptibility and more detrimental outcomes of COVID-19 in people with obesity. Clearly, this has important implications for preventive measures, vaccination, and future therapeutic strategies to combat COVID-19. Furthermore, we will highlight important knowledge gaps and provide suggestions for future research and recommendations for policy actions. Since many new reports on COVID-19 rapidly appear, the present perspective should be seen as a focus for discussion to drive forward further understanding, research initiatives, and clinical management of COVID-19.
Original language | English |
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Pages (from-to) | 439-452 |
Number of pages | 14 |
Journal | Obesity Facts |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- ACE2
- CORONAVIRUS
- COVID-19
- Coronavirus disease 2019
- EASO POSITION STATEMENT
- IMMUNITY
- INFECTIONS
- INFLAMMATION
- INFLUENZA
- Immune response
- OUTBREAK
- Obesity
- PATHOPHYSIOLOGY
- PNEUMONIA
- RECEPTOR
- RENIN-ANGIOTENSIN SYSTEM
- RISK
- Renin-angiotensin-aldosterone system
- SARS-CoV-2
- Severe acute respiratory syndrome coronavirus 2