Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity

Gijs H. Goossens*, Dror Dicker, Nathalie J. Farpour-Lambert, Gema Fruehbeck, Dana Mullerova, Euan Woodward, Jens-Christian Holm

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Web of Science)

Abstract

Accumulating evidence suggests that obesity is a major risk factor for the initiation, progression, and outcomes of coronavirus disease 2019 (COVID-19). The European Association for the Study of Obesity (EASO), as a scientific and medical society dedicated to the promotion of health and well-being, is greatly concerned about the concomitant obesity and COVID-19 pandemics and their impact on health and society at large. In this perspective, we will address the inherent immunological perturbations and alterations in the renin-angiotensin-aldosterone system in patients with obesity and COVID-19, and discuss how these impairments may underlie the increased susceptibility and more detrimental outcomes of COVID-19 in people with obesity. Clearly, this has important implications for preventive measures, vaccination, and future therapeutic strategies to combat COVID-19. Furthermore, we will highlight important knowledge gaps and provide suggestions for future research and recommendations for policy actions. Since many new reports on COVID-19 rapidly appear, the present perspective should be seen as a focus for discussion to drive forward further understanding, research initiatives, and clinical management of COVID-19.

Original languageEnglish
Pages (from-to)439-452
Number of pages14
JournalObesity Facts
Volume13
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • ACE2
  • CORONAVIRUS
  • COVID-19
  • Coronavirus disease 2019
  • EASO POSITION STATEMENT
  • IMMUNITY
  • INFECTIONS
  • INFLAMMATION
  • INFLUENZA
  • Immune response
  • Obesity
  • PATHOPHYSIOLOGY
  • PNEUMONIA
  • RECEPTOR
  • RENIN-ANGIOTENSIN SYSTEM
  • RISK
  • Renin-angiotensin-aldosterone system
  • SARS-CoV-2
  • Severe acute respiratory syndrome coronavirus 2
  • OUTBREAK

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