OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

Maud Alligier, Romain Barres, Ellen E. Blaak, Yves Boirie, Jildau Bouwman, Paul Brunault, Kristina Campbell, Karine Clement, I. Sadaf Farooqi, Nathalie J. Farpour-Lambert, Gema Fruhbeck, Gijs H. Goossens, Jorg Hager, Jason C. G. Halford, Hans Hauner, David Jacobi, Chantal Julia, Dominique Langin, Andrea Natali, Martin NeoviusJean Michel Oppert, Uberto Pagotto, Antonio L. Palmeira, Helen Roche, Mikael Ryden, Andre J. Scheen, Chantal Simon, Thorkild I. A. Sorensen, Luc Tappy, Hannele Yki-Jarvinen, Olivier Ziegler, Martine Laville*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.

Original languageEnglish
Pages (from-to)1-28
Number of pages28
JournalObesity Facts
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Obesity
  • Interventions
  • Variables
  • Precision medicine
  • Stratification
  • CORONARY-HEART-DISEASE
  • QUALITY-OF-LIFE
  • OBSTRUCTIVE SLEEP-APNEA
  • C-REACTIVE PROTEIN
  • BODY-MASS INDEX
  • GASTRIC BYPASS-SURGERY
  • WEIGHT-LOSS
  • PHYSICAL-ACTIVITY
  • METABOLIC SYNDROME
  • CARDIOVASCULAR-DISEASE

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