@article{8aa62f0bf094481d87eb7bb4a267d049,
title = "OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions",
abstract = "Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.",
keywords = "Obesity, Interventions, Variables, Precision medicine, Stratification, CORONARY-HEART-DISEASE, QUALITY-OF-LIFE, OBSTRUCTIVE SLEEP-APNEA, C-REACTIVE PROTEIN, BODY-MASS INDEX, GASTRIC BYPASS-SURGERY, WEIGHT-LOSS, PHYSICAL-ACTIVITY, METABOLIC SYNDROME, CARDIOVASCULAR-DISEASE",
author = "Maud Alligier and Romain Barres and Blaak, {Ellen E.} and Yves Boirie and Jildau Bouwman and Paul Brunault and Kristina Campbell and Karine Clement and Farooqi, {I. Sadaf} and Farpour-Lambert, {Nathalie J.} and Gema Fruhbeck and Goossens, {Gijs H.} and Jorg Hager and Halford, {Jason C. G.} and Hans Hauner and David Jacobi and Chantal Julia and Dominique Langin and Andrea Natali and Martin Neovius and Oppert, {Jean Michel} and Uberto Pagotto and Palmeira, {Antonio L.} and Helen Roche and Mikael Ryden and Scheen, {Andre J.} and Chantal Simon and Sorensen, {Thorkild I. A.} and Luc Tappy and Hannele Yki-Jarvinen and Olivier Ziegler and Martine Laville",
note = "Funding Information: The OBEDIS work with European experts occurred in parallel with a similar United States initiative funded by the National Institutes of Health: the ADOPT (Accumulating Data to Optimally Predict obesity Treatment) core measures project [3]. In the OBEDIS workshop, the experts noted that the existence of this parallel work highlights the need for such efforts in the field. OBEDIS scientists wish to connect ideas across these two projects and build joint efforts in the same direction, for the overall benefit of the field globally. Funding Information: K. Cl{\'e}ment is a consultant for Danone Research and LNC therapeutics for work unassociated with the present study. M. Neovius has received advisory board fees from Itrim and Ethicon Johnson & Johnson. L. Tappy received a research grant from Soremartec Italy srl and speaker{\textquoteright}s fees from Soremartec Italy srl and Nestl{\'e} AG, Switzerland. No other authors have conflicts of interest to declare. Publisher Copyright: {\textcopyright} 2020 The Author(s) Published by S. Karger AG, Basel.",
year = "2020",
month = feb,
doi = "10.1159/000505342",
language = "English",
volume = "13",
pages = "1--28",
journal = "Obesity Facts",
issn = "1662-4025",
publisher = "Karger",
number = "1",
}