Nutritional depletion and dietary manipulation: effects on the immune response.

K.W.E. Hulsewé*, B.A.C. van Acker, M.F. von Meyenfeldt, P.B. Soeters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Department of Surgery, University Hospital Maastricht, P. Debyelaan 25, 6202AZ Maastricht, The Netherlands.

The association between nutritional depletion and the increased susceptibility for infectious diseases has been recognized for a long time. The complexity of the immune system, however, makes it difficult to unravel the underlying mechanisms. It appears that depletion adversely affects virtually all components of the immune system. This review provides an overview over the specific requirements of substrates by immune cells and the effects of nutritional depletion on various components of the immune response, with special attention to gut-associated lymphoid tissue. The literature concerning effects of dietary interventions with specific nutrients on the immune response is also discussed. Finally, we offer a hypothesis with regard to the improvement of composition of "trauma" nutrition solutions.

Publication Types:
Review, Tutorial
Original languageEnglish
Pages (from-to)536-544
Number of pages9
JournalWorld Journal of Surgery
Issue number6
Publication statusPublished - 1 Jan 1999

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