Nutrition and health-transforming research traditions

J.C. Hanekamp*, A. Bast, E.J. Calabrese

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Abstract In this contribution we show that current scientific methodologies used in nutrition science and by regulatory agencies, such as the randomised control trial, limit our understanding of nutrition and health as they are to crude to capture the subtle pleiotropic nature of most nutrients. Thereby, regulatory agencies such as the European Food Safety Authority curb the development of scientific knowledge and industrial innovations within the nutritional field. In order to develop insights into the health impact of certain food and food-components, we need to realise that health is adaptation set within a homeostatic range. Increased performance of health, i.e. the maximum stimulation of health, typically seems 30-60% greater than the control group, with a width of no more than about a factor of ten, clarifying the difficulty of documenting responses of food-endogenous components within the homeostatic range of healthy people. A strategy to record subtle responses of food components is the summation of procentual effects of relevant health outcomes. We illustrate this approach with the action of flavanols on vascular health, specifically endothelial function.
Original languageEnglish
Pages (from-to)1072-1078
JournalCritical Reviews in Food Science and Nutrition
Issue number8
Publication statusPublished - 2015

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