Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation

Frederik De Smet; Mirian Saiz Rubio; Daphne Hompes; Evelyne Naus; Greet De Baets; Tobias Langenberg; Mark S. Hipp; Bert Houben; Filip Claes; Sarah Charbonneau; Javier Delgado Blanco; Stephane Plaisance; Shakti Ramkissoon; Lori Ramkissoon; Colinda Simons; Piet van den Brandt; Matty Weijenberg; Manon Van Engeland; Sandrina Lambrechts; Frederic Amant; Andre D'Hoore; Keith L. Ligon; Xavier Sagaert; Joost Schymkowitz; Frederic Rousseau

doi:10.1002/path.4872

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation

Frederik De Smet, Mirian Saiz Rubio, Daphne Hompes, Evelyne Naus, Greet De Baets, Tobias Langenberg, Mark S. Hipp, Bert Houben, Filip Claes, Sarah Charbonneau, Javier Delgado Blanco, Stephane Plaisance, Shakti Ramkissoon, Lori Ramkissoon, Colinda Simons, Piet van den Brandt, Matty Weijenberg, Manon Van Engeland, Sandrina Lambrechts, Frederic AmantAndre D'Hoore, Keith L. Ligon, Xavier Sagaert, Joost Schymkowitz^*, Frederic Rousseau^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	24-38
Number of pages	15
Journal	Journal of Pathology
Volume	242
Issue number	1
DOIs	https://doi.org/10.1002/path.4872
Publication status	Published - May 2017

Keywords

p53 aggregation
proteostasis
colon cancer
glioblastoma
nuclear inclusion bodies
UBIQUITIN-PROTEASOME SYSTEM
HEAT-SHOCK RESPONSE
PROTEIN AGGREGATION
NEURODEGENERATIVE DISEASES
HUNTINGTONS-DISEASE
CELLULAR-MODEL
A-BETA
GAIN
PML
MDM2

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10.1002/path.4872

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Cite this

De Smet, F., Rubio, M. S., Hompes, D., Naus, E., De Baets, G., Langenberg, T., Hipp, M. S., Houben, B., Claes, F., Charbonneau, S., Blanco, J. D., Plaisance, S., Ramkissoon, S., Ramkissoon, L., Simons, C., van den Brandt, P., Weijenberg, M., Van Engeland, M., Lambrechts, S., ... Rousseau, F. (2017). Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation. Journal of Pathology, 242(1), 24-38. https://doi.org/10.1002/path.4872

De Smet, Frederik ; Rubio, Mirian Saiz ; Hompes, Daphne ; Naus, Evelyne ; De Baets, Greet ; Langenberg, Tobias ; Hipp, Mark S. ; Houben, Bert ; Claes, Filip ; Charbonneau, Sarah ; Blanco, Javier Delgado ; Plaisance, Stephane ; Ramkissoon, Shakti ; Ramkissoon, Lori ; Simons, Colinda ; van den Brandt, Piet ; Weijenberg, Matty ; Van Engeland, Manon ; Lambrechts, Sandrina ; Amant, Frederic ; D'Hoore, Andre ; Ligon, Keith L. ; Sagaert, Xavier ; Schymkowitz, Joost ; Rousseau, Frederic. / Nuclear inclusion bodies of mutant and wild-type p53 in cancer : a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation. In: Journal of Pathology. 2017 ; Vol. 242, No. 1. pp. 24-38.

@article{cfd5529546f14dc7b09a6fbe5b2127ee,

title = "Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation",

keywords = "p53 aggregation, proteostasis, colon cancer, glioblastoma, nuclear inclusion bodies, UBIQUITIN-PROTEASOME SYSTEM, HEAT-SHOCK RESPONSE, PROTEIN AGGREGATION, NEURODEGENERATIVE DISEASES, HUNTINGTONS-DISEASE, CELLULAR-MODEL, A-BETA, GAIN, PML, MDM2",

author = "{De Smet}, Frederik and Rubio, {Mirian Saiz} and Daphne Hompes and Evelyne Naus and {De Baets}, Greet and Tobias Langenberg and Hipp, {Mark S.} and Bert Houben and Filip Claes and Sarah Charbonneau and Blanco, {Javier Delgado} and Stephane Plaisance and Shakti Ramkissoon and Lori Ramkissoon and Colinda Simons and {van den Brandt}, Piet and Matty Weijenberg and {Van Engeland}, Manon and Sandrina Lambrechts and Frederic Amant and Andre D'Hoore and Ligon, {Keith L.} and Xavier Sagaert and Joost Schymkowitz and Frederic Rousseau",

year = "2017",

month = may,

doi = "10.1002/path.4872",

language = "English",

volume = "242",

pages = "24--38",

journal = "Journal of Pathology",

issn = "0022-3417",

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number = "1",

}

De Smet, F, Rubio, MS, Hompes, D, Naus, E, De Baets, G, Langenberg, T, Hipp, MS, Houben, B, Claes, F, Charbonneau, S, Blanco, JD, Plaisance, S, Ramkissoon, S, Ramkissoon, L, Simons, C , van den Brandt, P , Weijenberg, M , Van Engeland, M , Lambrechts, S, Amant, F, D'Hoore, A, Ligon, KL, Sagaert, X, Schymkowitz, J & Rousseau, F 2017, 'Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation', Journal of Pathology, vol. 242, no. 1, pp. 24-38. https://doi.org/10.1002/path.4872

Nuclear inclusion bodies of mutant and wild-type p53 in cancer : a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation. / De Smet, Frederik; Rubio, Mirian Saiz; Hompes, Daphne; Naus, Evelyne; De Baets, Greet; Langenberg, Tobias; Hipp, Mark S.; Houben, Bert; Claes, Filip; Charbonneau, Sarah; Blanco, Javier Delgado; Plaisance, Stephane; Ramkissoon, Shakti; Ramkissoon, Lori; Simons, Colinda ; van den Brandt, Piet ; Weijenberg, Matty ; Van Engeland, Manon ; Lambrechts, Sandrina; Amant, Frederic; D'Hoore, Andre; Ligon, Keith L.; Sagaert, Xavier; Schymkowitz, Joost; Rousseau, Frederic.

In: Journal of Pathology, Vol. 242, No. 1, 05.2017, p. 24-38.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Nuclear inclusion bodies of mutant and wild-type p53 in cancer

T2 - a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation

AU - De Smet, Frederik

AU - Rubio, Mirian Saiz

AU - Hompes, Daphne

AU - Naus, Evelyne

AU - De Baets, Greet

AU - Langenberg, Tobias

AU - Hipp, Mark S.

AU - Houben, Bert

AU - Claes, Filip

AU - Charbonneau, Sarah

AU - Blanco, Javier Delgado

AU - Plaisance, Stephane

AU - Ramkissoon, Shakti

AU - Ramkissoon, Lori

AU - Simons, Colinda

AU - van den Brandt, Piet

AU - Weijenberg, Matty

AU - Van Engeland, Manon

AU - Lambrechts, Sandrina

AU - Amant, Frederic

AU - D'Hoore, Andre

AU - Ligon, Keith L.

AU - Sagaert, Xavier

AU - Schymkowitz, Joost

AU - Rousseau, Frederic

PY - 2017/5

Y1 - 2017/5

KW - p53 aggregation

KW - proteostasis

KW - colon cancer

KW - glioblastoma

KW - nuclear inclusion bodies

KW - UBIQUITIN-PROTEASOME SYSTEM

KW - HEAT-SHOCK RESPONSE

KW - PROTEIN AGGREGATION

KW - NEURODEGENERATIVE DISEASES

KW - HUNTINGTONS-DISEASE

KW - CELLULAR-MODEL

KW - A-BETA

KW - GAIN

KW - PML

KW - MDM2

U2 - 10.1002/path.4872

DO - 10.1002/path.4872

M3 - Article

C2 - 28035683

VL - 242

SP - 24

EP - 38

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 1

ER -