Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation

Frederik De Smet, Mirian Saiz Rubio, Daphne Hompes, Evelyne Naus, Greet De Baets, Tobias Langenberg, Mark S. Hipp, Bert Houben, Filip Claes, Sarah Charbonneau, Javier Delgado Blanco, Stephane Plaisance, Shakti Ramkissoon, Lori Ramkissoon, Colinda Simons, Piet van den Brandt, Matty Weijenberg, Manon Van Engeland, Sandrina Lambrechts, Frederic AmantAndre D'Hoore, Keith L. Ligon, Xavier Sagaert, Joost Schymkowitz, Frederic Rousseau

Research output: Contribution to journalArticleAcademicpeer-review

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Original languageEnglish
Pages (from-to)24-38
Number of pages15
JournalJournal of Pathology
Volume242
Issue number1
DOIs
Publication statusPublished - May 2017

Keywords

  • p53 aggregation
  • proteostasis
  • colon cancer
  • glioblastoma
  • nuclear inclusion bodies
  • UBIQUITIN-PROTEASOME SYSTEM
  • HEAT-SHOCK RESPONSE
  • PROTEIN AGGREGATION
  • NEURODEGENERATIVE DISEASES
  • HUNTINGTONS-DISEASE
  • CELLULAR-MODEL
  • A-BETA
  • GAIN
  • PML
  • MDM2

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