Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers.

R. van den Berg, G.R.M.M. Haenen, H. van den Berg, A. Bast

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Abstract

1382-6689 2001 Mar;9(4):147-151 Related Articles, Books, LinkOut


Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers.

van den Berg R, Haenen GR, van den Berg H, Bast A.

TNO Nutrition and Food Research, Department of Nutritional Physiology, Utrechtseweg 48, PO Box 360, 3700 AJ, Zeist, The Netherlands

Nuclear factor-kappaB (NF-kappaB) is an oxidative stress sensitive transcription factor involved in the regulation of inflammatory genes. Activation of NF-kappaB results into increased expression of inflammatory genes such as for interleukins, endothelial cell leukocyte adhesion molecules and inducible NO synthase. Our study, with six smokers and 10 non-smokers, showed that NF-kappaB activity in peripheral blood mononuclear cells of smokers compared to non-smokers is significantly higher (P<0.05). This indicates that NF-kappaB is involved in cigarette smoke induced inflammatory responses and that NF-kappaB activation can be used as a functional marker of oxidative stress.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalEnvironmental Toxicology and Pharmacology
Volume9
DOIs
Publication statusPublished - 1 Jan 2001

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