Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas

Robbert D. A. Weren; Arjen R. Mensenkamp; Michiel Simons; Astrid Eijkelenboom; Aisha S. Sie; Hicham Ouchene; Monique van Asseldonk; Encarna B. Gomez-Garcia; Marinus J. Blok; Joanne A. de Hullu; Marcel R. Nelen; Alexander Hoischen; Johan Bulten; Bastiaan B. J. Tops; Nicoline Hoogerbrugge; Marjolijn J. L. Ligtenberg

doi:10.1002/humu.23137

Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas

Robbert D. A. Weren, Arjen R. Mensenkamp, Michiel Simons, Astrid Eijkelenboom, Aisha S. Sie, Hicham Ouchene, Monique van Asseldonk, Encarna B. Gomez-Garcia, Marinus J. Blok, Joanne A. de Hullu, Marcel R. Nelen, Alexander Hoischen, Johan Bulten, Bastiaan B. J. Tops, Nicoline Hoogerbrugge, Marjolijn J. L. Ligtenberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	226-235
Number of pages	10
Journal	Human Mutation
Volume	38
Issue number	2
DOIs	https://doi.org/10.1002/humu.23137
Publication status	Published - Feb 2017

Keywords

ovarian cancer
BRCA1
BRCA2
cancer predisposition
BRCA testing
personalized medicine
PARP-inhibitor
single molecule molecular inversion probes
MOLECULAR INVERSION PROBES
RANDOMIZED PHASE-2 TRIAL
POLY(ADP-RIBOSE) POLYMERASE
SOMATIC MUTATIONS
PREDICTS SENSITIVITY
CANCER INCIDENCE
RISK-ASSESSMENT
BREAST
GERMLINE
OLAPARIB

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10.1002/humu.23137

Cite this

Weren, R. D. A., Mensenkamp, A. R., Simons, M., Eijkelenboom, A., Sie, A. S., Ouchene, H., van Asseldonk, M., Gomez-Garcia, E. B., Blok, M. J., de Hullu, J. A., Nelen, M. R., Hoischen, A., Bulten, J., Tops, B. B. J., Hoogerbrugge, N., & Ligtenberg, M. J. L. (2017). Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas. Human Mutation, 38(2), 226-235. https://doi.org/10.1002/humu.23137

Weren, Robbert D. A. ; Mensenkamp, Arjen R. ; Simons, Michiel ; Eijkelenboom, Astrid ; Sie, Aisha S. ; Ouchene, Hicham ; van Asseldonk, Monique ; Gomez-Garcia, Encarna B. ; Blok, Marinus J. ; de Hullu, Joanne A. ; Nelen, Marcel R. ; Hoischen, Alexander ; Bulten, Johan ; Tops, Bastiaan B. J. ; Hoogerbrugge, Nicoline ; Ligtenberg, Marjolijn J. L. / Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas. In: Human Mutation. 2017 ; Vol. 38, No. 2. pp. 226-235.

@article{3fbdaaf021584279994217585eb83be5,

title = "Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas",

keywords = "ovarian cancer, BRCA1, BRCA2, cancer predisposition, BRCA testing, personalized medicine, PARP-inhibitor, single molecule molecular inversion probes, MOLECULAR INVERSION PROBES, RANDOMIZED PHASE-2 TRIAL, POLY(ADP-RIBOSE) POLYMERASE, SOMATIC MUTATIONS, PREDICTS SENSITIVITY, CANCER INCIDENCE, RISK-ASSESSMENT, BREAST, GERMLINE, OLAPARIB",

author = "Weren, {Robbert D. A.} and Mensenkamp, {Arjen R.} and Michiel Simons and Astrid Eijkelenboom and Sie, {Aisha S.} and Hicham Ouchene and {van Asseldonk}, Monique and Gomez-Garcia, {Encarna B.} and Blok, {Marinus J.} and {de Hullu}, {Joanne A.} and Nelen, {Marcel R.} and Alexander Hoischen and Johan Bulten and Tops, {Bastiaan B. J.} and Nicoline Hoogerbrugge and Ligtenberg, {Marjolijn J. L.}",

year = "2017",

month = feb,

doi = "10.1002/humu.23137",

language = "English",

volume = "38",

pages = "226--235",

journal = "Human Mutation",

issn = "1059-7794",

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Weren, RDA, Mensenkamp, AR, Simons, M, Eijkelenboom, A, Sie, AS, Ouchene, H, van Asseldonk, M, Gomez-Garcia, EB , Blok, MJ, de Hullu, JA, Nelen, MR, Hoischen, A, Bulten, J, Tops, BBJ, Hoogerbrugge, N & Ligtenberg, MJL 2017, 'Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas', Human Mutation, vol. 38, no. 2, pp. 226-235. https://doi.org/10.1002/humu.23137

Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas. / Weren, Robbert D. A.; Mensenkamp, Arjen R.; Simons, Michiel; Eijkelenboom, Astrid; Sie, Aisha S.; Ouchene, Hicham; van Asseldonk, Monique; Gomez-Garcia, Encarna B.; Blok, Marinus J.; de Hullu, Joanne A.; Nelen, Marcel R.; Hoischen, Alexander; Bulten, Johan; Tops, Bastiaan B. J.; Hoogerbrugge, Nicoline; Ligtenberg, Marjolijn J. L.

In: Human Mutation, Vol. 38, No. 2, 02.2017, p. 226-235.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas

AU - Weren, Robbert D. A.

AU - Mensenkamp, Arjen R.

AU - Simons, Michiel

AU - Eijkelenboom, Astrid

AU - Sie, Aisha S.

AU - Ouchene, Hicham

AU - van Asseldonk, Monique

AU - Gomez-Garcia, Encarna B.

AU - Blok, Marinus J.

AU - de Hullu, Joanne A.

AU - Nelen, Marcel R.

AU - Hoischen, Alexander

AU - Bulten, Johan

AU - Tops, Bastiaan B. J.

AU - Hoogerbrugge, Nicoline

AU - Ligtenberg, Marjolijn J. L.

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KW - ovarian cancer

KW - BRCA1

KW - BRCA2

KW - cancer predisposition

KW - BRCA testing

KW - personalized medicine

KW - PARP-inhibitor

KW - single molecule molecular inversion probes

KW - MOLECULAR INVERSION PROBES

KW - RANDOMIZED PHASE-2 TRIAL

KW - POLY(ADP-RIBOSE) POLYMERASE

KW - SOMATIC MUTATIONS

KW - PREDICTS SENSITIVITY

KW - CANCER INCIDENCE

KW - RISK-ASSESSMENT

KW - BREAST

KW - GERMLINE

KW - OLAPARIB

U2 - 10.1002/humu.23137

DO - 10.1002/humu.23137

M3 - Article

C2 - 27767231

VL - 38

SP - 226

EP - 235

JO - Human Mutation

JF - Human Mutation

SN - 1059-7794

IS - 2

ER -