TY - JOUR
T1 - Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection
AU - Tonhajzerova, Ingrid
AU - Olexova, Lucia B.
AU - Jurko, Alexander
AU - Spronck, Bart
AU - Jurko, Tomas
AU - Sekaninova, Nikola
AU - Visnovcova, Zuzana
AU - Mestanikova, Andrea
AU - Kudela, Erik
AU - Mestanik, Michal
PY - 2019/8
Y1 - 2019/8
N2 - Cervical cancer is associated with a causative role of human papillomavirus (HPV), which is a highly prevalent infection. Recently, women with a genital HPV infection were found to have increased incidence of cardiovascular diseases (CVD), including severe cardiovascular events such as myocardial infarction and stroke. The pathomechanisms of this relation are not yet fully understood, and may significantly affect the health of a large part of the population. Accelerated atherosclerosis is assumed to play a key role in the pathophysiology of this relationship. To identify high-risk groups of the population, it is necessary to stratify the CVD risk. Current algorithms, as widely used for the estimation of CVD risk, seem to be limited by the individual misclassification of high-risk subjects. However, personalised prediction of cardiovascular events is missing. Regarding HPV-related CVD, identification of novel sensitive biomarkers reflecting early atherosclerotic changes could be of major importance for such personalised cardiovascular risk prediction. Therefore, this review focuses on the pathomechanisms leading to HPV-related cardiovascular diseases with respect to atherosclerosis, and the description of potential novel biomarkers to detect the earliest atherosclerotic changes important for the prevention of CVD in HPV infection and cervical cancer.
AB - Cervical cancer is associated with a causative role of human papillomavirus (HPV), which is a highly prevalent infection. Recently, women with a genital HPV infection were found to have increased incidence of cardiovascular diseases (CVD), including severe cardiovascular events such as myocardial infarction and stroke. The pathomechanisms of this relation are not yet fully understood, and may significantly affect the health of a large part of the population. Accelerated atherosclerosis is assumed to play a key role in the pathophysiology of this relationship. To identify high-risk groups of the population, it is necessary to stratify the CVD risk. Current algorithms, as widely used for the estimation of CVD risk, seem to be limited by the individual misclassification of high-risk subjects. However, personalised prediction of cardiovascular events is missing. Regarding HPV-related CVD, identification of novel sensitive biomarkers reflecting early atherosclerotic changes could be of major importance for such personalised cardiovascular risk prediction. Therefore, this review focuses on the pathomechanisms leading to HPV-related cardiovascular diseases with respect to atherosclerosis, and the description of potential novel biomarkers to detect the earliest atherosclerotic changes important for the prevention of CVD in HPV infection and cervical cancer.
KW - ANKLE VASCULAR INDEX
KW - ARTERIAL STIFFNESS
KW - BLOOD-PRESSURE
KW - DYSFUNCTION
KW - ENDOTHELIAL FUNCTION
KW - FLOW-MEDIATED DILATION
KW - HEALTH
KW - LIPID-METABOLISM
KW - RISK-FACTORS
KW - STATEMENT
KW - arterial stiffness
KW - cardiovascular disease
KW - endothelial function
KW - human papillomavirus
KW - PULSE PRESSURE
KW - TASK-FORCE
U2 - 10.3390/ijms20153720
DO - 10.3390/ijms20153720
M3 - (Systematic) Review article
C2 - 31366035
SN - 1661-6596
VL - 20
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 15
M1 - 3720
ER -