Abstract
Notecarin D (NotD) is a prothrombin (ProT) activator in the venom of the tiger snake, Notechis scutatus, and a factor Xa (FXa) homolog. NotD binds specifically to the FXa binding site expressed on factor V (FV) upon activation to factor Va (FVa) by thrombin. NotD active site-labeled with 5-fluorescein ([5F]FFR-NotD) binds FV and FVa with remarkably high affinity in the absence of phospholipids (K-D 12 and
Original language | English |
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Pages (from-to) | 38286-38297 |
Journal | Journal of Biological Chemistry |
Volume | 286 |
Issue number | 44 |
DOIs | |
Publication status | Published - 4 Nov 2011 |