Notch: Architect, Landscaper, and Guardian of the Intestine

Marc Vooijs*, Zhenyi Liu, Raphael Kopan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Web of Science)

Abstract

In the past decade, enormous progress has been made in understanding the role of stem cells in physiologic tissue renewal and in pathologic processes such as cancer. These findings have shed light on the identity and biological properties of such cells and the intrinsic and extrinsic signals that balance stem cell self-renewal with differentiation. With its astonishing self-renewal capacity, the intestinal epithelium has provided a unique model to study stem cell biology, lineage specification, and cancer. Here we review the role of Notch signaling in physiologic cell renewal and differentiation in the intestine as well as during its malignant transformation.
Original languageEnglish
Pages (from-to)448-459
JournalGastroenterology
Volume141
Issue number2
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Intestine
  • Stem Cells
  • Homeostasis
  • Notch
  • Colon Cancer

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