Noninvasive treatment alternative for intractable startle epilepsy

Sylvia Klinkenberg*, Sander Ubbink, Johannes Vles, Anton de Louw, Mariette Debeij van Hall, Dyon Scheijen, Jan Brokx

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We describe a treatment alternative for intractable, startle-provoked, epileptic seizures in four children aged between 8 and 14. Three of the four children had symptomatic localization-related epilepsy. They all suffered from intractable epilepsy precipitated by sudden sounds. The fact that seizures tended to occur with high frequency - more than one seizure a day - had a clear impact on daily life. Clinical seizure pattern demonstrated asymmetric tonic posturing in all four children. Three children experienced several seizure types including focal seizure onset. All children had focal neurological signs or learning disabilities or a combination of both. Our noninvasive treatment method using psychoeducational counseling and sound generators was applied in four children, resulting in a seizure frequency reduction of ≥ 50% in two of them.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalEpilepsy & behavior case reports
Publication statusPublished - 2014


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