Noninvasive imaging of hypoxia, hypoxia response and drug delivery : a bridge towards individualized patient treatment

L. Dubois

Research output: ThesisDoctoral ThesisInternal

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Abstract


Imaging (PET/CT scan) in cancer patients is an increasingly important element in both diagnosis and treatment. Hypoxia (lack of oxygen) is an important characteristic of tumours that causes resistance against cancer treatments. For efficient treatment of hypoxia it is important to know to which extent and where hypoxia is present in a tumour. This dissertation shows the possibility of determining hypoxia and the reaction of the cell to that low oxygen tension in a non-invasive way. We also proved that imaging is useful to follow the absorption of medication against cancer. Imaging will ultimately lead to an increased chance of survival by quicker and better selection of patients for specific treatments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Lambin, Philippe, Supervisor
  • Wouters, Brad, Supervisor
Award date11 Feb 2010
Place of PublicationMaastricht
Publisher
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • cancer
  • imaging
  • hypoxia

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