Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012

E. Mersy, L. J. M. Smits, L. A. A. P. van Winden, C. E. M. de Die-Smulders, A. D. C. Paulussen, M. V. E. Macville, A. B. C. Coumans, S. G. M. Frints*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Web of Science)
Original languageEnglish
Pages (from-to)318-329
JournalHuman Reproduction Update
Issue number4
Publication statusPublished - 2013


  • noninvasive prenatal testing
  • trisomy 21
  • cell-free fetal DNA
  • RNA
  • QUADAS-2

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