Non-small-cell lung cancer

Lizza E L Hendriks, Jordi Remon, Corinne Faivre-Finn, Marina C Garassino, John V Heymach, Keith M Kerr, Daniel S W Tan, Giulia Veronesi, Martin Reck*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is responsible for the majority of cancer-related deaths worldwide. The management of NSCLC has improved considerably, especially in the past 10 years. The systematic screening of populations at risk with low-dose CT, the implementation of novel surgical and radiotherapeutic techniques and a deeper biological understanding of NSCLC that has led to innovative systemic treatment options have improved the prognosis of patients with NSCLC. In non-metastatic NSCLC, the combination of various perioperative strategies and adjuvant immunotherapy in locally advanced disease seem to enhance cure rates. In metastatic NSCLC, the implementation of novel drugs might prolong disease control together with preserving quality of life. The further development of predictive clinical and genetic markers will be essential for the next steps in individualized treatment concepts.
Original languageEnglish
Article number71
JournalNature Reviews Disease Primers
Volume10
Issue number1
DOIs
Publication statusPublished - 26 Sept 2024

Keywords

  • Humans
  • Carcinoma, Non-Small-Cell Lung/therapy diagnosis
  • Lung Neoplasms/therapy diagnosis physiopathology
  • Quality of Life/psychology
  • Prognosis
  • Immunotherapy/methods

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