Abstract
Objective: Several linear electroencephalographic (EEG) measures at baseline have been demonstrated to be associated with treatment outcome after antidepressant treatment. In this study we investigated the added value of non-linear EEG metrics in the alpha band in predicting treatment outcome to repetitive transcranial magnetic stimulation (rTMS).
Methods: Subjects were 90 patients with major depressive disorder (MDD) and a group of 17 healthy controls (HC). MDD patients were treated with rTMS and psychotherapy for on average 21 sessions. Three non-linear EEG metrics (Lempel-Ziv Complexity (LZC); False Nearest Neighbors and Largest Lyapunov Exponent) were applied to the alpha band (7-13 Hz) for two 1-min epochs EEG and the association with treatment outcome was investigated.
Results: No differences were found between a subgroup of unmedicated MDD patients and the HC. Nonresponders showed a significant decrease in LZC from minute 1 to minute 2, whereas the responders and HC showed an increase in LZC.
Conclusions: There is no difference in EEG complexity between MDD and HC and the change in LZC across time demonstrated value in predicting outcome to rTMS.
Significance: This is the first study demonstrating utility of non-linear EEG metrics in predicting treatment outcome in MDD. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1392-1399 |
| Number of pages | 8 |
| Journal | Clinical Neurophysiology |
| Volume | 125 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2014 |
| Externally published | Yes |
Keywords
- rTMS
- EEG
- Signal processing
- Personalized medicine
- Depression
- Non-linear analysis
- Lempel-Ziv complexity
- TRANSCRANIAL MAGNETIC STIMULATION
- RANGE TEMPORAL CORRELATIONS
- HUMAN BRAIN
- TREATMENT RESPONSE
- DOUBLE-BLIND
- RESTING EEG
- ANTIDEPRESSANT
- METAANALYSIS
- DYNAMICS
- EFFICACY