Non-linear EEG analyses predict non-response to rTMS treatment in major depressive disorder

Martijn Arns*, Alexander Cerquera, Rafael M. Gutierrez, Fred Hasselman, Jan A. Freund

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Web of Science)

Abstract

Objective: Several linear electroencephalographic (EEG) measures at baseline have been demonstrated to be associated with treatment outcome after antidepressant treatment. In this study we investigated the added value of non-linear EEG metrics in the alpha band in predicting treatment outcome to repetitive transcranial magnetic stimulation (rTMS).

Methods: Subjects were 90 patients with major depressive disorder (MDD) and a group of 17 healthy controls (HC). MDD patients were treated with rTMS and psychotherapy for on average 21 sessions. Three non-linear EEG metrics (Lempel-Ziv Complexity (LZC); False Nearest Neighbors and Largest Lyapunov Exponent) were applied to the alpha band (7-13 Hz) for two 1-min epochs EEG and the association with treatment outcome was investigated.

Results: No differences were found between a subgroup of unmedicated MDD patients and the HC. Nonresponders showed a significant decrease in LZC from minute 1 to minute 2, whereas the responders and HC showed an increase in LZC.

Conclusions: There is no difference in EEG complexity between MDD and HC and the change in LZC across time demonstrated value in predicting outcome to rTMS.

Significance: This is the first study demonstrating utility of non-linear EEG metrics in predicting treatment outcome in MDD. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1392-1399
Number of pages8
JournalClinical Neurophysiology
Volume125
Issue number7
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • rTMS
  • EEG
  • Signal processing
  • Personalized medicine
  • Depression
  • Non-linear analysis
  • Lempel-Ziv complexity
  • TRANSCRANIAL MAGNETIC STIMULATION
  • RANGE TEMPORAL CORRELATIONS
  • HUMAN BRAIN
  • TREATMENT RESPONSE
  • DOUBLE-BLIND
  • RESTING EEG
  • ANTIDEPRESSANT
  • METAANALYSIS
  • DYNAMICS
  • EFFICACY

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