Non-invasive diagnostic of head and neck cancer: Feasibility of a portable electronic nose

Martinus Gerardus Eimbertus van de Goor

Research output: ThesisDoctoral ThesisInternal


This thesis investigated the feasibility of electronic nose technology for the diagnostic of primarily head and neck cancer and secondary lung cancer and recurrent head and neck cancer. E-noses were engineered to mimic the mammalian olfactory system within an instrument designed to obtain repeatable measurements, allowing the identification and classification of volatile organic compound patterns. The instrument combines a signal transduction mechanism with a pattern recognition algorithm to create a model. The model is used to classify a sample as sick or healthy. This thesis has demonstrated the potential of an e-nose as a non-invasive tool for cancer diagnostics, achieving an accuracy of 72% for head and neck cancer and 83% for lung cancer. However, further research is necessary in order for these models to be incorporated into our healthcare system as a diagnostic instrument.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Kremer, B., Supervisor
  • Kross, K.W., Co-Supervisor, External person
Award date3 Mar 2023
Place of PublicationMaastricht
Publication statusPublished - 2023


  • head and neck cancer
  • electronic nose
  • diagnostics
  • artificial intelligence


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