Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Christian Bar; Shambhabi Chatterjee; Ines Falcao Pires; Patricia Rodrigues; Joost P. G. Sluijter; Reinier A. Boon; Rosa M. Nevado; Vicente Andres; Marida Sansonetti; Leon de Windt; Michele Ciccarelli; Nazha Hamdani; Stephane Heymans; Raquel Figuinha Videira; Carlo G. Tocchetti; Mauro Giacca; Serena Zacchigna; Stefan Engelhardt; Stefanie Dimmeler; Rosalinda Madonna; Thomas Thum

doi:10.1093/cvr/cvaa195

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Christian Bar, Shambhabi Chatterjee, Ines Falcao Pires, Patricia Rodrigues, Joost P. G. Sluijter, Reinier A. Boon, Rosa M. Nevado, Vicente Andres, Marida Sansonetti, Leon de Windt, Michele Ciccarelli, Nazha Hamdani, Stephane Heymans, Raquel Figuinha Videira, Carlo G. Tocchetti, Mauro Giacca, Serena Zacchigna, Stefan Engelhardt, Stefanie Dimmeler, Rosalinda MadonnaThomas Thum^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

Original language	English
Pages (from-to)	1805-1819
Number of pages	15
Journal	Cardiovascular Research
Volume	116
Issue number	11
DOIs	https://doi.org/10.1093/cvr/cvaa195
Publication status	Published - 1 Sept 2020
Event	Myocardial Function and Cellular Biology of the Heart: Joint Meeting of the European Society of Cardiology (ESC) Working Groups - Naples, Italy Duration: 9 May 2019 → 11 May 2019

Keywords

Cardiovascular disease
Non-coding RNA
MicroRNA
Remodelling
Regeneration
Aging
Non-coding RNA therapy
DOXORUBICIN-INDUCED CARDIOTOXICITY
CARDIAC RESYNCHRONIZATION THERAPY
CARDIOMYOCYTE PROLIFERATION
ENDOTHELIAL-CELLS
CIRCULATING MICRORNAS
INFLAMMATORY RESPONSE
NATRIURETIC-PEPTIDE
VENTRICULAR FAILURE
EXOSOMAL TRANSFER
IN-VITRO

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10.1093/cvr/cvaa195Licence: Free access - publisher

Cite this

Bar, C., Chatterjee, S., Pires, I. F., Rodrigues, P., Sluijter, J. P. G., Boon, R. A., Nevado, R. M., Andres, V., Sansonetti, M., de Windt, L., Ciccarelli, M., Hamdani, N., Heymans, S., Videira, R. F., Tocchetti, C. G., Giacca, M., Zacchigna, S., Engelhardt, S., Dimmeler, S., ... Thum, T. (2020). Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular Research, 116(11), 1805-1819. https://doi.org/10.1093/cvr/cvaa195

@article{35871960977440e7a243fc5184b3ff91,

title = "Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart",

abstract = "Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.",

keywords = "Cardiovascular disease, Non-coding RNA, MicroRNA, Remodelling, Regeneration, Aging, Non-coding RNA therapy, DOXORUBICIN-INDUCED CARDIOTOXICITY, CARDIAC RESYNCHRONIZATION THERAPY, CARDIOMYOCYTE PROLIFERATION, ENDOTHELIAL-CELLS, CIRCULATING MICRORNAS, INFLAMMATORY RESPONSE, NATRIURETIC-PEPTIDE, VENTRICULAR FAILURE, EXOSOMAL TRANSFER, IN-VITRO",

author = "Christian Bar and Shambhabi Chatterjee and Pires, {Ines Falcao} and Patricia Rodrigues and Sluijter, {Joost P. G.} and Boon, {Reinier A.} and Nevado, {Rosa M.} and Vicente Andres and Marida Sansonetti and {de Windt}, Leon and Michele Ciccarelli and Nazha Hamdani and Stephane Heymans and Videira, {Raquel Figuinha} and Tocchetti, {Carlo G.} and Mauro Giacca and Serena Zacchigna and Stefan Engelhardt and Stefanie Dimmeler and Rosalinda Madonna and Thomas Thum",

note = "Funding Information: T.T. and C.B. were supported by Deutsche Forschungsgemeinschaft, DFG (TRR267) and the ERANet CVD (JTC2016 project EXPERT to T.T. and JTC2018 project INNOVATION to C.B.). C.G.T. was supported by a 'Federico II University/Ricerca di Ateneo' grant. I.F.P. is supported by Fundo Europeu de Desenvolvimento Regional (FEDER) through Compete 2020-Programa Operacional Competitividade E Internacionaliza{\c c}{\~a}o (POCI), the project NETDIAMOND (POCI-01-0145-FEDER-016385), supported by European Structural and Investment Funds, Lisbon's regional operational programme 2020. P.R. is funded by FCT (SFRH/BD/96026/2013). R.M. was supported by a Cardio-Oncology grants from Incyte s.r.l. and funds from Ministero dell'Istruzione, Universit{\`a} e Ricerca Scientifica (549901_ 2020_Madonna: Ateneo). N.H. was supported by Deutsche Forschungsgemeinschaft, DFG (HA7512/2-1). J.P.G.S. was supported by the Project EVICARE (No. 725229) of the European Research Council (ERC). V.A.'s laboratory received support from the Instituto de Salud Carlos III (ISCIII) (grant AC16/00091, as member of the ERA-CVD JCT2016 EXPERT Network, European Union's Horizon 2020 Framework Programme), with co-funding from the European Regional Development Fund (ERDF/FEDER, 'Una manera de hacer Europa'). R.M.N. is supported by the Ministerio de Educaci{\'o}n, Cultura y Deporte (predoctoral contract FPU16/05027). The CNIC is supported by the Spanish Ministerio de Ciencia e Innovaci{\'o}n (MCI), the ISCIII, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Publisher Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. {\textcopyright} The Author(s) 2020.; Myocardial Function and Cellular Biology of the Heart : Joint Meeting of the European Society of Cardiology (ESC) Working Groups ; Conference date: 09-05-2019 Through 11-05-2019",

year = "2020",

month = sep,

day = "1",

doi = "10.1093/cvr/cvaa195",

language = "English",

volume = "116",

pages = "1805--1819",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "11",

}

Bar, C, Chatterjee, S, Pires, IF, Rodrigues, P, Sluijter, JPG, Boon, RA, Nevado, RM, Andres, V, Sansonetti, M, de Windt, L, Ciccarelli, M, Hamdani, N, Heymans, S, Videira, RF, Tocchetti, CG, Giacca, M, Zacchigna, S, Engelhardt, S, Dimmeler, S, Madonna, R & Thum, T 2020, 'Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart', Cardiovascular Research, vol. 116, no. 11, pp. 1805-1819. https://doi.org/10.1093/cvr/cvaa195

TY - JOUR

T1 - Non-coding RNAs

T2 - Myocardial Function and Cellular Biology of the Heart

AU - Bar, Christian

AU - Chatterjee, Shambhabi

AU - Pires, Ines Falcao

AU - Rodrigues, Patricia

AU - Sluijter, Joost P. G.

AU - Boon, Reinier A.

AU - Nevado, Rosa M.

AU - Andres, Vicente

AU - Sansonetti, Marida

AU - de Windt, Leon

AU - Ciccarelli, Michele

AU - Hamdani, Nazha

AU - Heymans, Stephane

AU - Videira, Raquel Figuinha

AU - Tocchetti, Carlo G.

AU - Giacca, Mauro

AU - Zacchigna, Serena

AU - Engelhardt, Stefan

AU - Dimmeler, Stefanie

AU - Madonna, Rosalinda

AU - Thum, Thomas

N1 - Funding Information: T.T. and C.B. were supported by Deutsche Forschungsgemeinschaft, DFG (TRR267) and the ERANet CVD (JTC2016 project EXPERT to T.T. and JTC2018 project INNOVATION to C.B.). C.G.T. was supported by a 'Federico II University/Ricerca di Ateneo' grant. I.F.P. is supported by Fundo Europeu de Desenvolvimento Regional (FEDER) through Compete 2020-Programa Operacional Competitividade E Internacionalização (POCI), the project NETDIAMOND (POCI-01-0145-FEDER-016385), supported by European Structural and Investment Funds, Lisbon's regional operational programme 2020. P.R. is funded by FCT (SFRH/BD/96026/2013). R.M. was supported by a Cardio-Oncology grants from Incyte s.r.l. and funds from Ministero dell'Istruzione, Università e Ricerca Scientifica (549901_ 2020_Madonna: Ateneo). N.H. was supported by Deutsche Forschungsgemeinschaft, DFG (HA7512/2-1). J.P.G.S. was supported by the Project EVICARE (No. 725229) of the European Research Council (ERC). V.A.'s laboratory received support from the Instituto de Salud Carlos III (ISCIII) (grant AC16/00091, as member of the ERA-CVD JCT2016 EXPERT Network, European Union's Horizon 2020 Framework Programme), with co-funding from the European Regional Development Fund (ERDF/FEDER, 'Una manera de hacer Europa'). R.M.N. is supported by the Ministerio de Educación, Cultura y Deporte (predoctoral contract FPU16/05027). The CNIC is supported by the Spanish Ministerio de Ciencia e Innovación (MCI), the ISCIII, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Publisher Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

AB - Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

KW - Cardiovascular disease

KW - Non-coding RNA

KW - MicroRNA

KW - Remodelling

KW - Regeneration

KW - Aging

KW - Non-coding RNA therapy

KW - DOXORUBICIN-INDUCED CARDIOTOXICITY

KW - CARDIAC RESYNCHRONIZATION THERAPY

KW - CARDIOMYOCYTE PROLIFERATION

KW - ENDOTHELIAL-CELLS

KW - CIRCULATING MICRORNAS

KW - INFLAMMATORY RESPONSE

KW - NATRIURETIC-PEPTIDE

KW - VENTRICULAR FAILURE

KW - EXOSOMAL TRANSFER

KW - IN-VITRO

U2 - 10.1093/cvr/cvaa195

DO - 10.1093/cvr/cvaa195

M3 - Article

C2 - 32638021

SN - 0008-6363

VL - 116

SP - 1805

EP - 1819

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 11

Y2 - 9 May 2019 through 11 May 2019

ER -