Non-coding RNAs to treat vascular smooth muscle cell dysfunction

Simon D. Brown; Eftychia Klimi; Wilfried A. M. Bakker; Abdelaziz Beqqali; Andrew H. Baker

doi:10.1111/bph.16409

Non-coding RNAs to treat vascular smooth muscle cell dysfunction

Simon D. Brown, Eftychia Klimi, Wilfried A. M. Bakker, Abdelaziz Beqqali, Andrew H. Baker^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. We also discuss the prospects and challenges associated with developing ncRNA-based therapies for this prevalent type of cardiovascular pathology.image

Original language	English
Number of pages	35
Journal	British Journal of Pharmacology
DOIs	https://doi.org/10.1111/bph.16409
Publication status	E-pub ahead of print - 1 May 2024

Keywords

atherosclerosis
cardiovascular disease
circular RNA
long non-coding RNA
microRNA
non-coding RNA
therapeutic oligonucleotides
vascular smooth muscle cell
HEPATITIS-B-VACCINE
GENOME-WIDE ASSOCIATION
IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE
TRANSCRIPTION FACTOR DECOY
ABDOMINAL AORTIC-ANEURYSM
SPINAL MUSCULAR-ATROPHY
BYPASS GRAFT-SURGERY
VEIN GRAFT
CONCISE GUIDE
GENE-TRANSFER

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title = "Non-coding RNAs to treat vascular smooth muscle cell dysfunction",

abstract = "Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. We also discuss the prospects and challenges associated with developing ncRNA-based therapies for this prevalent type of cardiovascular pathology.image",

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author = "Brown, {Simon D.} and Eftychia Klimi and Bakker, {Wilfried A. M.} and Abdelaziz Beqqali and Baker, {Andrew H.}",

year = "2024",

month = may,

day = "1",

doi = "10.1111/bph.16409",

language = "English",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "Wiley",

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T1 - Non-coding RNAs to treat vascular smooth muscle cell dysfunction

AU - Brown, Simon D.

AU - Klimi, Eftychia

AU - Bakker, Wilfried A. M.

AU - Beqqali, Abdelaziz

AU - Baker, Andrew H.

PY - 2024/5/1

Y1 - 2024/5/1

N2 - Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. We also discuss the prospects and challenges associated with developing ncRNA-based therapies for this prevalent type of cardiovascular pathology.image

AB - Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. We also discuss the prospects and challenges associated with developing ncRNA-based therapies for this prevalent type of cardiovascular pathology.image

KW - atherosclerosis

KW - cardiovascular disease

KW - circular RNA

KW - long non-coding RNA

KW - microRNA

KW - non-coding RNA

KW - therapeutic oligonucleotides

KW - vascular smooth muscle cell

KW - HEPATITIS-B-VACCINE

KW - GENOME-WIDE ASSOCIATION

KW - IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE

KW - TRANSCRIPTION FACTOR DECOY

KW - ABDOMINAL AORTIC-ANEURYSM

KW - SPINAL MUSCULAR-ATROPHY

KW - BYPASS GRAFT-SURGERY

KW - VEIN GRAFT

KW - CONCISE GUIDE

KW - GENE-TRANSFER

U2 - 10.1111/bph.16409

DO - 10.1111/bph.16409

M3 - (Systematic) Review article

SN - 0007-1188

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

ER -

Non-coding RNAs to treat vascular smooth muscle cell dysfunction

Abstract

Keywords

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