TY - JOUR
T1 - Non-coding RNAs in Cardiac Intercellular Communication
AU - Videira, Raquel Figuinha
AU - da Costa Martins, Paula A.
N1 - Funding Information:
Funding. RV was supported by the Foundation for Science and Technology of Portugal (FCT) grant (SFRH/BD/129507/2017). PC was supported by a Dutch Heart Foundation grant (NHS2015T066).
Publisher Copyright:
© Copyright © 2020 Videira and da Costa Martins.
PY - 2020/9/9
Y1 - 2020/9/9
N2 - Intercellular communication allows for molecular information to be transferred from cell to cell, in order to maintain tissue or organ homeostasis. Alteration in the process due to changes, either on the vehicle or the cargo information, may contribute to pathological events, such as cardiac pathological remodeling. Extracellular vesicles (EVs), namely exosomes, are double-layer vesicles secreted by cells to mediate intercellular communication, both locally and systemically. EVs can carry different types of cargo, including non-coding RNAs (ncRNAs), which, are major regulators of physiological and pathological processes. ncRNAs transported in EVs are functionally active and trigger a cascade of processes in the recipient cells. Upon cardiac injury, exosomal ncRNAs can derive from and target different cardiac cell types to initiate cellular and molecular remodeling events such as hypertrophic growth, cardiac fibrosis, endothelial dysfunction, and inflammation, all contributing to cardiac dysfunction and, eventually, heart failure. Exosomal ncRNAs are currently accepted as crucial players in the process of cardiac pathological remodeling and alterations in their presence profile in EVs may attenuate cardiac dysfunction, suggesting that exosomal ncRNAs are potential new therapeutic targets. Here, we review the current research on the role of ncRNAs in intercellular communication, in the context of cardiac pathological remodeling.
AB - Intercellular communication allows for molecular information to be transferred from cell to cell, in order to maintain tissue or organ homeostasis. Alteration in the process due to changes, either on the vehicle or the cargo information, may contribute to pathological events, such as cardiac pathological remodeling. Extracellular vesicles (EVs), namely exosomes, are double-layer vesicles secreted by cells to mediate intercellular communication, both locally and systemically. EVs can carry different types of cargo, including non-coding RNAs (ncRNAs), which, are major regulators of physiological and pathological processes. ncRNAs transported in EVs are functionally active and trigger a cascade of processes in the recipient cells. Upon cardiac injury, exosomal ncRNAs can derive from and target different cardiac cell types to initiate cellular and molecular remodeling events such as hypertrophic growth, cardiac fibrosis, endothelial dysfunction, and inflammation, all contributing to cardiac dysfunction and, eventually, heart failure. Exosomal ncRNAs are currently accepted as crucial players in the process of cardiac pathological remodeling and alterations in their presence profile in EVs may attenuate cardiac dysfunction, suggesting that exosomal ncRNAs are potential new therapeutic targets. Here, we review the current research on the role of ncRNAs in intercellular communication, in the context of cardiac pathological remodeling.
KW - non-coding RNAs
KW - extracellular vesicles
KW - cardiac intercellular communication
KW - cardiac pathological remodeling
KW - heart failure
KW - MESENCHYMAL STEM-CELLS
KW - ATRIAL-NATRIURETIC-PEPTIDE
KW - EXTRACELLULAR VESICLES
KW - MYOCARDIAL-INFARCTION
KW - ENDOTHELIAL-CELLS
KW - HYPERTROPHY
KW - EXOSOMES
KW - HEART
KW - INFLAMMATION
KW - FIBROSIS
U2 - 10.3389/fphys.2020.00738
DO - 10.3389/fphys.2020.00738
M3 - (Systematic) Review article
C2 - 33013428
SN - 1664-042X
VL - 11
JO - Frontiers in physiology
JF - Frontiers in physiology
M1 - 738
ER -