No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction

D. R. J. van Mierlo; T. R. Lopez Penha; R. J. Schipper; M. H. Martens; J. Serroyen; M. B. I. Lobbes; E. M. Heuts; S. Tuinder; M. L. Smidt

doi:10.1016/j.breast.2013.08.002

No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction

D. R. J. van Mierlo, T. R. Lopez Penha^*, R. J. Schipper, M. H. Martens, J. Serroyen, M. B. I. Lobbes, E. M. Heuts, S. Tuinder, M. L. Smidt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy. Method: Patients that underwent IBR after SSM between 2004 and 2011 were included. Results: A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025). Conclusion: In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant.

Original language	English
Pages (from-to)	1166-1170
Journal	Breast
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.breast.2013.08.002
Publication status	Published - Dec 2013

Keywords

Breast cancer
Reconstructive surgical procedure
Local neoplasm recurrence
Post-operative complications

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@article{0ce43370f5f64398a6a94f4a00ed7b40,

title = "No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction",

abstract = "Background: The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy. Method: Patients that underwent IBR after SSM between 2004 and 2011 were included. Results: A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025). Conclusion: In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant. ",

keywords = "Breast cancer, Reconstructive surgical procedure, Local neoplasm recurrence, Post-operative complications",

author = "{van Mierlo}, {D. R. J.} and Penha, {T. R. Lopez} and Schipper, {R. J.} and Martens, {M. H.} and J. Serroyen and Lobbes, {M. B. I.} and Heuts, {E. M.} and S. Tuinder and Smidt, {M. L.}",

year = "2013",

month = dec,

doi = "10.1016/j.breast.2013.08.002",

language = "English",

volume = "22",

pages = "1166--1170",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

number = "6",

}

TY - JOUR

T1 - No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction

AU - van Mierlo, D. R. J.

AU - Penha, T. R. Lopez

AU - Schipper, R. J.

AU - Martens, M. H.

AU - Serroyen, J.

AU - Lobbes, M. B. I.

AU - Heuts, E. M.

AU - Tuinder, S.

AU - Smidt, M. L.

PY - 2013/12

Y1 - 2013/12

N2 - Background: The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy. Method: Patients that underwent IBR after SSM between 2004 and 2011 were included. Results: A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025). Conclusion: In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant.

AB - Background: The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy. Method: Patients that underwent IBR after SSM between 2004 and 2011 were included. Results: A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025). Conclusion: In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant.

KW - Breast cancer

KW - Reconstructive surgical procedure

KW - Local neoplasm recurrence

KW - Post-operative complications

U2 - 10.1016/j.breast.2013.08.002

DO - 10.1016/j.breast.2013.08.002

M3 - Article

C2 - 24025989

SN - 0960-9776

VL - 22

SP - 1166

EP - 1170

JO - Breast

JF - Breast

IS - 6

ER -

No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction

Abstract

Keywords

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