No effects of korean pine nut triacylglycerol on satiety and energy intake

ABSTRACT: BACKGROUND: Triacylglycerols (TAG) have been shown to have potential appetite suppressing effects. This study examined the effects of 3g and 6g Korean pine nut triacylglycerols (PinnoThin) on appetite and energy intake. METHODS: 130g Isoenergetic yogurt containing either placebo (milk fat) or PinnoThin TAG was consumed as a breakfast, after an overnight fast, in a double blind randomized crossover design. Appetite profile ratings were determined by visual analogue scale at regular intervals for a period of 4h after the breakfast. In phase I, 6g PinnoThin TAG and placebo was tested in thirty-three healthy women (mean+/-SD, BMI 26.4+/-3.8 kg/m2; age 28+/-10 y) to determine the appetite suppressing effect in time. In phase II, an additional dose of 3g PinnoThin TAG, as well as 6g PinnoThin TAG and placebo, was tested in thirty-four women (BMI 25.8+/-2.9 kg/m2; age 25+/-9 y) to determine energy intake from an ad libitum lunch offered at 210 min after the breakfast, at which maximal differences in appetite profile ratings were present in phase I. RESULTS: Area under the curve of appetite profile ratings was not significantly different between the conditions. Energy intake was 9.5% lower after 6g PinnoThin TAG compared with 3g PinnoThin TAG, but there was no significant difference with the placebo. CONCLUSION: A dosage of 6g PinnoThin TAG is not sufficient to suppress appetite and energy intake. Trial registration: Clinical Trials NCT01034605.