No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study

R.A. Armstrong; J.M. Chardigny; B. Beaufrere; L. Bretillon; S.H.F. Vermunt - Dongen; R.P. Mensink; A. McVean; R.A. Elton; J.L. Sebedio; R.A. Riemersma

doi:10.1016/S0049-3848(00)00309-1

No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study

R.A. Armstrong^*
, J.M. Chardigny
, B. Beaufrere
, L. Bretillon
, S.H.F. Vermunt - Dongen
, R.P. Mensink
, A. McVean
, R.A. Elton
, J.L. Sebedio
, R.A. Riemersma

^*Corresponding author for this work

NUTRIM - Institute of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of this study was to investigate the effect of trans alpha -linolenic acid on platelet aggregation and blood haemostasis. A randomized, double blind dietary intervention trial was carried out with healthy male volunteers (n=88) in three European centers. After a 6-week washout period where subjects avoided foods containing all trans fats, subjects either continued for 6 weeks with a low trans diet or a diet where trans alpha -linolenic acid provided 0.6% of energy (supplied as oil, margarine, cheese, muffins, and biscuits). At the end of the washout period the intake of trans polyunsaturated fats was 58+/-115 mg/day; this increased in patients on the high trans diet by +1344+/-328 mg/day, compared with +10+/-67 mg/day in patients on the low trans diet (p

Original language	English
Pages (from-to)	133-141
Number of pages	8
Journal	Thrombosis Research
Volume	100
Issue number	3
DOIs	https://doi.org/10.1016/S0049-3848(00)00309-1
Publication status	Published - 1 Jan 2000

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Armstrong, R. A., Chardigny, J. M., Beaufrere, B., Bretillon, L., Vermunt - Dongen, S. H. F., Mensink, R. P., McVean, A., Elton, R. A., Sebedio, J. L., & Riemersma, R. A. (2000). No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study. Thrombosis Research, 100(3), 133-141. https://doi.org/10.1016/S0049-3848(00)00309-1

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title = "No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study",

abstract = "The aim of this study was to investigate the effect of trans alpha -linolenic acid on platelet aggregation and blood haemostasis. A randomized, double blind dietary intervention trial was carried out with healthy male volunteers (n=88) in three European centers. After a 6-week washout period where subjects avoided foods containing all trans fats, subjects either continued for 6 weeks with a low trans diet or a diet where trans alpha -linolenic acid provided 0.6\% of energy (supplied as oil, margarine, cheese, muffins, and biscuits). At the end of the washout period the intake of trans polyunsaturated fats was 58+/-115 mg/day; this increased in patients on the high trans diet by +1344+/-328 mg/day, compared with +10+/-67 mg/day in patients on the low trans diet (p",

author = "R.A. Armstrong and J.M. Chardigny and B. Beaufrere and L. Bretillon and \{Vermunt - Dongen\}, S.H.F. and R.P. Mensink and A. McVean and R.A. Elton and J.L. Sebedio and R.A. Riemersma",

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Armstrong, RA, Chardigny, JM, Beaufrere, B, Bretillon, L, Vermunt - Dongen, SHF, Mensink, RP, McVean, A, Elton, RA, Sebedio, JL & Riemersma, RA 2000, 'No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study', Thrombosis Research, vol. 100, no. 3, pp. 133-141. https://doi.org/10.1016/S0049-3848(00)00309-1

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T1 - No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study

AU - Armstrong, R.A.

AU - Chardigny, J.M.

AU - Beaufrere, B.

AU - Bretillon, L.

AU - Vermunt - Dongen, S.H.F.

AU - Mensink, R.P.

AU - McVean, A.

AU - Elton, R.A.

AU - Sebedio, J.L.

AU - Riemersma, R.A.

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N2 - The aim of this study was to investigate the effect of trans alpha -linolenic acid on platelet aggregation and blood haemostasis. A randomized, double blind dietary intervention trial was carried out with healthy male volunteers (n=88) in three European centers. After a 6-week washout period where subjects avoided foods containing all trans fats, subjects either continued for 6 weeks with a low trans diet or a diet where trans alpha -linolenic acid provided 0.6% of energy (supplied as oil, margarine, cheese, muffins, and biscuits). At the end of the washout period the intake of trans polyunsaturated fats was 58+/-115 mg/day; this increased in patients on the high trans diet by +1344+/-328 mg/day, compared with +10+/-67 mg/day in patients on the low trans diet (p

AB - The aim of this study was to investigate the effect of trans alpha -linolenic acid on platelet aggregation and blood haemostasis. A randomized, double blind dietary intervention trial was carried out with healthy male volunteers (n=88) in three European centers. After a 6-week washout period where subjects avoided foods containing all trans fats, subjects either continued for 6 weeks with a low trans diet or a diet where trans alpha -linolenic acid provided 0.6% of energy (supplied as oil, margarine, cheese, muffins, and biscuits). At the end of the washout period the intake of trans polyunsaturated fats was 58+/-115 mg/day; this increased in patients on the high trans diet by +1344+/-328 mg/day, compared with +10+/-67 mg/day in patients on the low trans diet (p

U2 - 10.1016/S0049-3848(00)00309-1

DO - 10.1016/S0049-3848(00)00309-1

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JO - Thrombosis Research

JF - Thrombosis Research

IS - 3

ER -

No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study

Abstract

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