No effect of dietary trans isomers of a-linolenic acid on platelet aggregation and haemostatic factors in European healthy men: the TRANSLine Study

R.A. Armstrong*, J.M. Chardigny, B. Beaufrere, L. Bretillon, S.H.F. Vermunt - Dongen, R.P. Mensink, A. McVean, R.A. Elton, J.L. Sebedio, R.A. Riemersma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The aim of this study was to investigate the effect of trans alpha -linolenic acid on platelet aggregation and blood haemostasis. A randomized, double blind dietary intervention trial was carried out with healthy male volunteers (n=88) in three European centers. After a 6-week washout period where subjects avoided foods containing all trans fats, subjects either continued for 6 weeks with a low trans diet or a diet where trans alpha -linolenic acid provided 0.6% of energy (supplied as oil, margarine, cheese, muffins, and biscuits). At the end of the washout period the intake of trans polyunsaturated fats was 58+/-115 mg/day; this increased in patients on the high trans diet by +1344+/-328 mg/day, compared with +10+/-67 mg/day in patients on the low trans diet (p
Original languageEnglish
Pages (from-to)133-141
Number of pages8
JournalThrombosis Research
Issue number3
Publication statusPublished - 1 Jan 2000

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