No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Katharina Bey, Steffen Wolfsgruber, Ilker Karaca, Holger Wagner, Roy Lardenoije, Julian Becker, Esther Milz, Johannes Kornhuber, Oliver Peters, Lutz Froelich, Michael Huell, Eckart Ruether, Jens Wiltfang, Steffi Riedel-Heller, Martin Scherer, Frank Jessen, Wolfgang Maier, Daniel L. van den Hove, Bart P. F. Rutten, Michael WagnerAlfredo Ramirez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.
Original languageEnglish
Pages (from-to)593-598
JournalEpigenomics
Volume8
Issue number5
DOIs
Publication statusPublished - May 2016

Keywords

  • aging
  • Alzheimer's disease
  • cognitive decline
  • DNA methylation
  • DNA methyltransferase 3a
  • DNMT3A
  • epigenetics
  • MCI
  • mild cognitive impairment
  • rs11887120

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