No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

An M. Voets; Cary Oberije; Robin B. Struijk; Bart Reymen; Kim De Ruyck; Hubert Thierens; Katrien Vandecasteele; Wilfried De Neve; Ruud Houben; Dirk De Ruysscher; Hubert J. M. Smeets; Philippe Lambin

doi:10.1016/j.radonc.2012.09.016

No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

An M. Voets, Cary Oberije, Robin B. Struijk, Bart Reymen, Kim De Ruyck, Hubert Thierens, Katrien Vandecasteele, Wilfried De Neve, Ruud Houben, Dirk De Ruysscher, Hubert J. M. Smeets, Philippe Lambin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study aimed at validating the previously published association between TGF-beta 1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.

Original language	English
Pages (from-to)	296-298
Journal	Radiotherapy and Oncology
Volume	105
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2012.09.016
Publication status	Published - Dec 2012

Keywords

Lung cancer
Radiotherapy
Dyspnea
TGF-beta 1
Polymorphisms

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Voets, A. M., Oberije, C., Struijk, R. B., Reymen, B., De Ruyck, K., Thierens, H., Vandecasteele, K., De Neve, W., Houben, R., De Ruysscher, D., Smeets, H. J. M., & Lambin, P. (2012). No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients. Radiotherapy and Oncology, 105(3), 296-298. https://doi.org/10.1016/j.radonc.2012.09.016

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title = "No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients",

abstract = "This study aimed at validating the previously published association between TGF-beta 1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score. ",

keywords = "Lung cancer, Radiotherapy, Dyspnea, TGF-beta 1, Polymorphisms",

author = "Voets, {An M.} and Cary Oberije and Struijk, {Robin B.} and Bart Reymen and {De Ruyck}, Kim and Hubert Thierens and Katrien Vandecasteele and {De Neve}, Wilfried and Ruud Houben and {De Ruysscher}, Dirk and Smeets, {Hubert J. M.} and Philippe Lambin",

year = "2012",

month = dec,

doi = "10.1016/j.radonc.2012.09.016",

language = "English",

volume = "105",

pages = "296--298",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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}

Voets, AM, Oberije, C, Struijk, RB, Reymen, B, De Ruyck, K, Thierens, H, Vandecasteele, K, De Neve, W, Houben, R, De Ruysscher, D, Smeets, HJM & Lambin, P 2012, 'No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients', Radiotherapy and Oncology, vol. 105, no. 3, pp. 296-298. https://doi.org/10.1016/j.radonc.2012.09.016

TY - JOUR

T1 - No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

AU - Voets, An M.

AU - Oberije, Cary

AU - Struijk, Robin B.

AU - Reymen, Bart

AU - De Ruyck, Kim

AU - Thierens, Hubert

AU - Vandecasteele, Katrien

AU - De Neve, Wilfried

AU - Houben, Ruud

AU - De Ruysscher, Dirk

AU - Smeets, Hubert J. M.

AU - Lambin, Philippe

PY - 2012/12

Y1 - 2012/12

N2 - This study aimed at validating the previously published association between TGF-beta 1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.

AB - This study aimed at validating the previously published association between TGF-beta 1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.

KW - Lung cancer

KW - Radiotherapy

KW - Dyspnea

KW - TGF-beta 1

KW - Polymorphisms

U2 - 10.1016/j.radonc.2012.09.016

DO - 10.1016/j.radonc.2012.09.016

M3 - Article

C2 - 23127773

SN - 0167-8140

VL - 105

SP - 296

EP - 298

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

Abstract

Keywords

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