No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

An M. Voets, Cary Oberije, Robin B. Struijk, Bart Reymen, Kim De Ruyck, Hubert Thierens, Katrien Vandecasteele, Wilfried De Neve, Ruud Houben, Dirk De Ruysscher, Hubert J. M. Smeets, Philippe Lambin*

*Corresponding author for this work

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Abstract

This study aimed at validating the previously published association between TGF-beta 1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.
Original languageEnglish
Pages (from-to)296-298
JournalRadiotherapy and Oncology
Volume105
Issue number3
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Lung cancer
  • Radiotherapy
  • Dyspnea
  • TGF-beta 1
  • Polymorphisms

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