TY - JOUR
T1 - N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
AU - Morales-Garcia, Jose A.
AU - Calleja-Conde, Javier
AU - Lopez-Moreno, Jose A.
AU - Alonso-Gil, Sandra
AU - Sanz-SanCristobal, Marina
AU - Riba, Jordi
AU - Perez-Castillo, Ana
N1 - Funding Information:
This work was supported by the MINECO (SAF2017-85199-P to A.P.-C.) and was partially financed with FEDER funds. J.R. received funding from the Beckley Foundation. CIBERNED is funded by the Health Institute “Carlos III”.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/9/28
Y1 - 2020/9/28
N2 - N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of the hippocampus, promoting newly generated neurons in the granular zone. Moreover, these mice performed better, compared to control non-treated animals, in memory tests, which suggest a functional relevance for the DMT-induced new production of neurons in the hippocampus. Interestingly, the neurogenic effect of DMT appears to involve signaling via sigma-1 receptor (S1R) activation since S1R antagonist blocked the neurogenic effect. Taken together, our results demonstrate that DMT treatment activates the subgranular neurogenic niche regulating the proliferation of neural stem cells, the migration of neuroblasts, and promoting the generation of new neurons in the hippocampus, therefore enhancing adult neurogenesis and improving spatial learning and memory tasks
AB - N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of the hippocampus, promoting newly generated neurons in the granular zone. Moreover, these mice performed better, compared to control non-treated animals, in memory tests, which suggest a functional relevance for the DMT-induced new production of neurons in the hippocampus. Interestingly, the neurogenic effect of DMT appears to involve signaling via sigma-1 receptor (S1R) activation since S1R antagonist blocked the neurogenic effect. Taken together, our results demonstrate that DMT treatment activates the subgranular neurogenic niche regulating the proliferation of neural stem cells, the migration of neuroblasts, and promoting the generation of new neurons in the hippocampus, therefore enhancing adult neurogenesis and improving spatial learning and memory tasks
KW - NEURAL STEM-CELLS
KW - SIGMA-1 RECEPTOR
KW - HIPPOCAMPAL NEUROGENESIS
KW - DENTATE GYRUS
KW - RECURRENT DEPRESSION
KW - PROLIFERATION
KW - DIFFERENTIATION
KW - ASTROCYTES
KW - NEURONS
KW - MEMORY
U2 - 10.1038/s41398-020-01011-0
DO - 10.1038/s41398-020-01011-0
M3 - Article
C2 - 32989216
SN - 2158-3188
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 331
ER -