Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Ashok Aspatwar, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1064-1073
Number of pages10
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume33
Issue number1
DOIs
Publication statusPublished - 17 Jun 2018

Keywords

  • Nitroimidazoles
  • carbonic anhydrase IX
  • zebrafish
  • Xenopus oocytes
  • in vivo inhibition
  • CARBONIC-ANHYDRASE-IX
  • CANCER-THERAPY
  • PH REGULATION
  • ISOZYME-IX
  • TOXICITY
  • HYPOXIA
  • MODEL
  • ETHOXZOLAMIDE
  • TUBERCULOSIS
  • BICARBONATE

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