Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Ashok Aspatwar*, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1064-1073
Number of pages10
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume33
Issue number1
DOIs
Publication statusPublished - 17 Jun 2018

Keywords

  • Nitroimidazoles
  • carbonic anhydrase IX
  • zebrafish
  • Xenopus oocytes
  • in vivo inhibition
  • CARBONIC-ANHYDRASE-IX
  • CANCER-THERAPY
  • PH REGULATION
  • ISOZYME-IX
  • TOXICITY
  • HYPOXIA
  • MODEL
  • ETHOXZOLAMIDE
  • TUBERCULOSIS
  • BICARBONATE

Cite this