Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells

Ploingarm Petsophonsakul, Mathias Burgmaier, Brecht Willems, Sylvia Heeneman, Nadina Stadler, Felix Gremse, Sebastian Reith, Kathrin Burgmaier, Florian Kahles, Nikolaus Marx, Ehsan Natour, Elham Bidar, Michael Jacobs, Barend Mees, Chris Reutelingsperger, Malgorzata Furmanik, Leon Schurgers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)
Original languageEnglish
Number of pages15
JournalCardiovascular Research
DOIs
Publication statusE-pub ahead of print - 17 Jul 2021

Keywords

  • Nicotine Vascular calcification Vascular smooth muscle cell phenotypic switching Nox5 Vitamin K2
  • CORONARY-ARTERY CALCIFICATION
  • NECROSIS-FACTOR-ALPHA
  • VITAMIN-K
  • CIGARETTE-SMOKING
  • FETUIN-A
  • SUBCLINICAL ATHEROSCLEROSIS
  • CARDIOVASCULAR-DISEASE
  • CALCIUM-PHOSPHATE
  • AORTIC-ANEURYSMS
  • UP-REGULATION

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