Abstract
Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production.
Method: In this review, an effort was made to address the basic background or NGS technologies, potential applications of NGS in drug designing. Our purpose is also to provide a brief introduction of various Next-generation sequencing techniques.
Discussions: The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of Massively Parallel Sequencing (MPS) or NGS technologies. The Next gene involved necessarily executes Large-scale Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human genome can be sequenced within a single day.
Conclusion: Analysis of NGS data unravels important clues in the quest for the treatment of various life threatening diseases and other related scientific problems related to human welfare.
Original language | English |
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Pages (from-to) | 3350-3357 |
Number of pages | 8 |
Journal | Current Pharmaceutical Design |
Volume | 25 |
Issue number | 31 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Next generation sequencing
- drug discovery
- high throughput sequencing
- infectious disease
- human welfare
- Large-scale Unbiased Sequencing (LUS)
- HIGH-THROUGHPUT
- DNA
- TECHNOLOGIES
- CHALLENGES
- GENOMICS
- INSIGHTS