New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Chiara Brullo, Roberta Ricciarelli, Jos Prickaerts, Ottavio. Arancio, Matteo Massa, Chiara Rotolo, Alessia Romussi, Claudia Rebosio, Barbara Marengo, Maria Adelaide Pronzato, Britt T. J. van Hagen, Nick P. van Goethem, Pasqualina D'Ursi, Alessandro Orro, Luciano Milanesi, Sara Guariento, Elena Cichero, Paola Fossa, Ernesto Fedele, Olga Bruno*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)82-102
JournalEuropean Journal of Medicinal Chemistry
Volume124
DOIs
Publication statusPublished - 29 Nov 2016

Keywords

  • PDE4D inhibitors
  • cAMP enhancers
  • Memory behavior test
  • Pharmacoldnetic analyses
  • Molecular dynamics simulation
  • In silico ADMET properties

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