New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Chiara Brullo, Roberta Ricciarelli, Jos Prickaerts, Ottavio. Arancio, Matteo Massa, Chiara Rotolo, Alessia Romussi, Claudia Rebosio, Barbara Marengo, Maria Adelaide Pronzato, Britt T. J. van Hagen, Nick P. van Goethem, Pasqualina D'Ursi, Alessandro Orro, Luciano Milanesi, Sara Guariento, Elena Cichero, Paola Fossa, Ernesto Fedele, Olga Bruno

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
Original languageEnglish
Pages (from-to)82-102
JournalEuropean Journal of Medicinal Chemistry
Volume124
DOIs
Publication statusPublished - 29 Nov 2016

Keywords

  • PDE4D inhibitors
  • cAMP enhancers
  • Memory behavior test
  • Pharmacoldnetic analyses
  • Molecular dynamics simulation
  • In silico ADMET properties

Cite this

Brullo, Chiara ; Ricciarelli, Roberta ; Prickaerts, Jos ; Arancio, Ottavio. ; Massa, Matteo ; Rotolo, Chiara ; Romussi, Alessia ; Rebosio, Claudia ; Marengo, Barbara ; Pronzato, Maria Adelaide ; van Hagen, Britt T. J. ; van Goethem, Nick P. ; D'Ursi, Pasqualina ; Orro, Alessandro ; Milanesi, Luciano ; Guariento, Sara ; Cichero, Elena ; Fossa, Paola ; Fedele, Ernesto ; Bruno, Olga. / New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment. In: European Journal of Medicinal Chemistry. 2016 ; Vol. 124. pp. 82-102.
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title = "New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment",
keywords = "PDE4D inhibitors, cAMP enhancers, Memory behavior test, Pharmacoldnetic analyses, Molecular dynamics simulation, In silico ADMET properties",
author = "Chiara Brullo and Roberta Ricciarelli and Jos Prickaerts and Ottavio. Arancio and Matteo Massa and Chiara Rotolo and Alessia Romussi and Claudia Rebosio and Barbara Marengo and Pronzato, {Maria Adelaide} and {van Hagen}, {Britt T. J.} and {van Goethem}, {Nick P.} and Pasqualina D'Ursi and Alessandro Orro and Luciano Milanesi and Sara Guariento and Elena Cichero and Paola Fossa and Ernesto Fedele and Olga Bruno",
year = "2016",
month = "11",
day = "29",
doi = "10.1016/j.ejmech.2016.08.018",
language = "English",
volume = "124",
pages = "82--102",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier France-Editions Scientifiques et Medicales Elsevier",

}

Brullo, C, Ricciarelli, R, Prickaerts, J, Arancio, O, Massa, M, Rotolo, C, Romussi, A, Rebosio, C, Marengo, B, Pronzato, MA, van Hagen, BTJ, van Goethem, NP, D'Ursi, P, Orro, A, Milanesi, L, Guariento, S, Cichero, E, Fossa, P, Fedele, E & Bruno, O 2016, 'New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment', European Journal of Medicinal Chemistry, vol. 124, pp. 82-102. https://doi.org/10.1016/j.ejmech.2016.08.018

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment. / Brullo, Chiara; Ricciarelli, Roberta; Prickaerts, Jos; Arancio, Ottavio.; Massa, Matteo; Rotolo, Chiara; Romussi, Alessia; Rebosio, Claudia; Marengo, Barbara; Pronzato, Maria Adelaide; van Hagen, Britt T. J.; van Goethem, Nick P.; D'Ursi, Pasqualina; Orro, Alessandro; Milanesi, Luciano; Guariento, Sara; Cichero, Elena; Fossa, Paola; Fedele, Ernesto; Bruno, Olga.

In: European Journal of Medicinal Chemistry, Vol. 124, 29.11.2016, p. 82-102.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

AU - Brullo, Chiara

AU - Ricciarelli, Roberta

AU - Prickaerts, Jos

AU - Arancio, Ottavio.

AU - Massa, Matteo

AU - Rotolo, Chiara

AU - Romussi, Alessia

AU - Rebosio, Claudia

AU - Marengo, Barbara

AU - Pronzato, Maria Adelaide

AU - van Hagen, Britt T. J.

AU - van Goethem, Nick P.

AU - D'Ursi, Pasqualina

AU - Orro, Alessandro

AU - Milanesi, Luciano

AU - Guariento, Sara

AU - Cichero, Elena

AU - Fossa, Paola

AU - Fedele, Ernesto

AU - Bruno, Olga

PY - 2016/11/29

Y1 - 2016/11/29

KW - PDE4D inhibitors

KW - cAMP enhancers

KW - Memory behavior test

KW - Pharmacoldnetic analyses

KW - Molecular dynamics simulation

KW - In silico ADMET properties

U2 - 10.1016/j.ejmech.2016.08.018

DO - 10.1016/j.ejmech.2016.08.018

M3 - Article

VL - 124

SP - 82

EP - 102

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -