New avenues to target Wnt/beta-catenin signaling

Folkert Verkaar, Guido J. R. Zaman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Wnt/beta-catenin signaling is an evolutionarily conserved signaling cascade with imperative roles during development and in adult stem cell maintenance. Hyperactivation of Wnt/beta-catenin drives various cancers, whereas hypoactivation underlies bone malformations and neurodegenerative disorders. Although several small molecule modulators of Wnt/beta-catenin signaling have been identified, none have progressed into clinical trials yet. Recent studies employing genomics and proteomics approaches have yielded more druggable targets, such as kinases and seven-transmembrane receptors. In addition, new assay methods enable a more targeted approach for high-throughput screening of this pathway and are expected to deliver clinical candidates in the coming decade.
Original languageEnglish
Pages (from-to)35-41
JournalDrug Discovery Today
Issue number1-2
Publication statusPublished - Jan 2011


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