Abstract
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.
Original language | English |
---|---|
Pages (from-to) | 736-743 |
Number of pages | 8 |
Journal | Circulation Research |
Volume | 120 |
Issue number | 4 |
DOIs | |
Publication status | Published - Feb 2017 |
Keywords
- atherosclerosis
- coronary artery disease
- extracellular trap
- neutrophils
- thrombosis
- ACUTE MYOCARDIAL-INFARCTION
- PLASMACYTOID DENDRITIC CELLS
- SYSTEMIC-LUPUS-ERYTHEMATOSUS
- PAPILLON-LEFEVRE-SYNDROME
- ACUTE CORONARY SYNDROMES
- THROMBUS FORMATION
- IN-VIVO
- CHROMATIN DECONDENSATION
- POSITIVE NEUTROPHILS
- NETTING NEUTROPHILS