Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis

Yvonne Doering*, Oliver Soehnlein, Christian Weber

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

199 Citations (Web of Science)

Abstract

Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.

Original languageEnglish
Pages (from-to)736-743
Number of pages8
JournalCirculation Research
Volume120
Issue number4
DOIs
Publication statusPublished - Feb 2017

Keywords

  • atherosclerosis
  • coronary artery disease
  • extracellular trap
  • neutrophils
  • thrombosis
  • ACUTE MYOCARDIAL-INFARCTION
  • PLASMACYTOID DENDRITIC CELLS
  • SYSTEMIC-LUPUS-ERYTHEMATOSUS
  • PAPILLON-LEFEVRE-SYNDROME
  • ACUTE CORONARY SYNDROMES
  • THROMBUS FORMATION
  • IN-VIVO
  • CHROMATIN DECONDENSATION
  • POSITIVE NEUTROPHILS
  • NETTING NEUTROPHILS

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