Neuroprotection in neurodegenerative processes associated with Parkinsonism and aging: Correlation between dopaminergic neuronal death and glial activation

Ana Luisa Gil Martinez

Research output: ThesisDoctoral ThesisExternal prepared

Abstract

The rapid aging of the world population will lead to an increase in cases of Parkinson's disease, challenging health systems in the coming decades. Some medications compensate for this lack of dopamine, but they are far from being perfect. Thus, it is necessary the research focus on the mechanisms involved in the cell death, as the neuroinflammatory processes, in order to develop new therapeutic strategies. One of the most promising ideas is the so-called “drug repositioning” which consists in the process of developing a compound for use in a different disease. In this work, we found that N-acetil-L-cysteine (a common mucolitic drug with anti-oxidant properties) protects against neuroinflammation and neuronal death. Thus, these data point out the importance in the development of this strategy to slow down the progression of the neurodegeneration in Parkinson's disease.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • University of Murcia
Supervisors/Advisors
  • Steinbusch, Harry, Supervisor
  • Herrero Ezquerro, Maria-Trinidad, Supervisor, External person
Award date24 Jun 2019
Publication statusPublished - 2019

Keywords

  • Aging population
  • Parkinson’s disease
  • Neuroinflammation
  • drug repositioning
  • Neurodegeneration

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