Neuropathic pain: Identification of tissue-specific molecular signatures

Chronic neuropathic pain (CNP) is a prevalent condition with diverse causes, making treatment challenging. Defined by the IASP as pain from somatosensory nervous system damage, less than half of patients find relief despite existing guidelines. Management largely relies on trial-and-error, with limited success in translating pathophysiological insights into therapies. Diagnostic methods mainly involve clinical evaluation, lacking molecular precision for subgroup identification. Thus, this thesis aims to uncover objective biomarkers and explore new potential approaches to better differentiate patient groups for tailored treatments.