Neuronal identity and maturation: insights from the single-cell transcriptome

Mark van den Hurk

Research output: ThesisDoctoral ThesisInternal

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Abstract

Advances in stem cell technology have made it possible to reprogramme the skin cells of patients and healthy individuals in a lab to create nerve cells (neurons) for neuroscientific research purposes. Despite the success of this method, the high degree of diversity in the maturity and functionality of neurons appears to impede an accurate comparison of sick and healthy cells. Using advanced analysis methods at the individual cell level and molecular level, this dissertation characterises the various functional properties of reprogrammed neurons. The ability to use molecular techniques to isolate and compare neurons with the same functional capability makes research on the genetic and biological basis of neurological and psychiatric conditions easier and more accurate to carry out.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Steinbusch, Harry, Supervisor
  • Rutten, Bart, Supervisor
  • Kenis, Gunter, Supervisor
  • Bardy, Cedric, Advisor, External person
Award date13 Dec 2016
Place of PublicationMaastricht
Publisher
Print ISBNs9789461699893
Publication statusPublished - 2016

Keywords

  • stem cell technology
  • neuronal diversity
  • functional maturation
  • biomarkers

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