Neuromodulation in Psychiatric Disorders

Yasin Temel*, Sarah A. Hescham, Ali Jahanshahi, Marcus L. F. Janssen, Sonny K. H. Tan, Jacobus J. van Overbeeke, Linda Ackermans, Mayke Oosterloo, Annelien Duits, Albert F. G. Leentjens, LeeWei Lim

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

22 Citations (Web of Science)

Abstract

Psychiatric disorders are worldwide a common cause of severe and long-term disability and socioeconomic burden. The management of patients with psychiatric disorders consists of drug therapy and/or psychotherapy. However, in some patients, these treatment modalities do not produce sufficient therapeutic effects or induce intolerable side effects. For these patients, neuromodulation has been suggested as a potential treatment modality. Neuromodulation includes deep brain stimulation, vagal nerve stimulation, and transcranial magnetic and electrical stimulation. The rationale for neuromodulation is derived from the research identifying neurobiologically localized substrates for refractory psychiatric symptoms. Here, we review the clinical data on neuromodulation in the major psychiatric disorders. Relevant data from animal models will also be discussed to explain the neurobiological basis of the therapy.
Original languageEnglish
Title of host publicationEMERGING HORIZONS IN NEUROMODULATION: NEW FRONTIERS IN BRAIN AND SPINE STIMULATION
Pages283-314
Volume107
DOIs
Publication statusPublished - 2012

Publication series

SeriesInternational Review of Neurobiology

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