Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a 1H-MRS study

Oron Levin, Wouter A J Vints*, Gal Ziv, Gintarė Katkutė, Simona Kušleikienė, Kristina Valatkevičienė, Samrat Sheoran, Margarita Drozdova-Statkevičienė, Rymantė Gleiznienė, Mati Pääsuke, Vilma Dudonienė, Uwe Himmelreich, Vida J Česnaitienė, Nerijus Masiulis

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Proton magnetic resonance spectroscopy (1H-MRS) holds promise for revealing and understanding neurodegenerative processes associated with cognitive and functional impairments in aging. In the present study, we examined the neurometabolic correlates of balance performance in 42 cognitively intact older adults (healthy controls - HC) and 26 older individuals that were diagnosed with mild cognitive impairment (MCI). Neurometabolite ratios of total N-acetyl aspartate (tNAA), glutamate-glutamine complex (Glx), total choline (tCho) and myo-inositol (mIns) relative to total creatine (tCr) were assessed using single voxel 1H-MRS in four different brain regions. Regions of interest were the left hippocampus (HPC), dorsal posterior cingulate cortex (dPCC), left sensorimotor cortex (SM1), and right dorsolateral prefrontal cortex (dlPFC). Center-of-pressure velocity (Vcop) and dual task effect (DTE) were used as measures of balance performance. Results indicated no significant group differences in neurometabolite ratios and balance performance measures. However, our observations revealed that higher tCho/tCr and mIns/tCr in hippocampus and dPCC were generic predictors of worse balance performance, suggesting that neuroinflammatory processes in these regions might be a driving factor for impaired balance performance in aging. Further, we found that higher tNAA/tCr and mIns/tCr and lower Glx/tCr in left SM1 were predictors of better balance performance in MCI but not in HC. The latter observation hints at the possibility that individuals with MCI may upregulate balance control through recruitment of sensorimotor pathways.

Original languageEnglish
Article number103304
Number of pages11
JournalNeuroImage: Clinical
Issue number1
Early online date24 Dec 2022
Publication statusPublished - 2023


Dive into the research topics of 'Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a 1H-MRS study'. Together they form a unique fingerprint.

Cite this