Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders

Roy Lardenoije, Ehsan Pishva, Katie Lunnon, Daniel L. van den Hove*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

14 Citations (Web of Science)

Abstract

Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current state of play for epigenetic research into neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and Huntington's disease. We focus on the recent evidence for a potential role of DNA modifications, histone modifications and non-coding RNA in the etiology of these disorders. Finally, we discuss how new technological and bioinformatics advances in the field of epigenetics could further progress our understanding about the underlying mechanisms of neurodegenerative diseases.
Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
Subtitle of host publicationNeuroepigenetics and mental illness
EditorsBart P.F. Rutten
Place of PublicationSan Diego, CA
PublisherElsevier Inc.
Chapter4
Pages49-82
Number of pages34
Volume158
Edition1
ISBN (Electronic)9780128125939
ISBN (Print)9780128125922
DOIs
Publication statusPublished - 31 Jul 2018

Publication series

SeriesProgress in Molecular Biology and Translational Science
ISSN1877-1173

Keywords

  • AMYLOID-PRECURSOR-PROTEIN
  • ALPHA-SYNUCLEIN EXPRESSION
  • PARKINSONS-DISEASE PATIENTS
  • BRAIN S-ADENOSYLMETHIONINE
  • NF-KAPPA-B
  • ALZHEIMERS-DISEASE
  • DNA METHYLATION
  • HISTONE ACETYLATION
  • MOUSE MODEL
  • LIFE-SPAN

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