TY - JOUR
T1 - Neuroendocrine carcinoma in a patient with Birt-Hogg-Dube syndrome
AU - Claessens, Tijs
AU - Weppler, Sherry A.
AU - van Geel, Michel
AU - Creytens, David
AU - Vreeburg, Maaike
AU - Wouters, Bradley
AU - van Steensel, Maurice A. M.
PY - 2010/10
Y1 - 2010/10
N2 - Background. A patient with Birt-Hogg-Dube syndrome (BHD) presented with gross hematuria of 6 months' duration. Imaging revealed the presence of a mass in the left prostatic lobe, in addition to a previously observed renal mass. Prostate biopsy and imaging findings indicated an inflammatory etiology, and the patient was discharged. 5 months later, the patient presented once again with urinary retention. During transurethral resection of the prostate, a mass adjacent to the bladder was observed. Postoperative imaging revealed a large pelvic mass, a second mass impinging on the rectum, and extensive lymphadenopathy. The patient died 2 weeks later. Investigations. CT and MRI, physical examination, measurement of serum markers, urinalysis, transrectal prostate biopsy, histopathological and genetic examination of tumor specimens, postmortem immunohistochemical analysis. Diagnosis. Neuroendocrine carcinoma of prostate or bladder origin. Management. The patient died before planned chemotherapy or radiation therapy could be implemented. More-frequent monitoring of the patient might have led to earlier diagnosis and allowed treatment to be started before widespread tumor metastasis and invasion.
AB - Background. A patient with Birt-Hogg-Dube syndrome (BHD) presented with gross hematuria of 6 months' duration. Imaging revealed the presence of a mass in the left prostatic lobe, in addition to a previously observed renal mass. Prostate biopsy and imaging findings indicated an inflammatory etiology, and the patient was discharged. 5 months later, the patient presented once again with urinary retention. During transurethral resection of the prostate, a mass adjacent to the bladder was observed. Postoperative imaging revealed a large pelvic mass, a second mass impinging on the rectum, and extensive lymphadenopathy. The patient died 2 weeks later. Investigations. CT and MRI, physical examination, measurement of serum markers, urinalysis, transrectal prostate biopsy, histopathological and genetic examination of tumor specimens, postmortem immunohistochemical analysis. Diagnosis. Neuroendocrine carcinoma of prostate or bladder origin. Management. The patient died before planned chemotherapy or radiation therapy could be implemented. More-frequent monitoring of the patient might have led to earlier diagnosis and allowed treatment to be started before widespread tumor metastasis and invasion.
U2 - 10.1038/nrurol.2010.140
DO - 10.1038/nrurol.2010.140
M3 - Article
C2 - 20842188
SN - 1759-4812
VL - 7
SP - 583
EP - 587
JO - Nature Reviews Urology
JF - Nature Reviews Urology
IS - 10
ER -