TY - JOUR
T1 - Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis
AU - Zonnenberg, I.A.
AU - van Dijk-Lokkart, E.M.
AU - van den Dungen, F.A.M.
AU - Vermeulen, R.J.
AU - van Weissenbruch, M.M.
N1 - Funding Information:
This study was funded by Fonds Nuts Ohra.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. This prospective cohort study aims to establish the effect of sepsis after 72 h of life on cognitive, psychomotor, and language development of preterm infants (below 32 weeks gestational age and/or below 1500 g). At 2 years corrected age, neurodevelopmental outcome was tested using Bayley's Scales of Infant Development-II, Lexilijst (lexical development questionnaire), and behavior checklists. Of 117 patients included, 85 experienced blood culture-proven infection. Coagulase-negative staphylococci were responsible for 55% of the episodes. No significant differences were found in cognitive, motor, and behavioral scores or lexiquotient comparing patients with versus no proven infection. When comparing three groups (coagulase-negative staphylococci, other, and negative blood culture), a significant difference was found in composite cognitive scores (p = 0.016), in favor of the coagulase-negative staphylococci group versus other causal agent group (p = 0.007). No significant differences were found in other subscales.Conclusion: In this cohort, no differences were found in neurodevelopmental outcome at 2 years corrected age between proven and no proven infection groups; confirmation in larger cohorts with a control group is needed. Patients encountering coagulase-negative staphylococci sepsis showed a significant better cognitive outcome compared to other causal agents.
AB - Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. This prospective cohort study aims to establish the effect of sepsis after 72 h of life on cognitive, psychomotor, and language development of preterm infants (below 32 weeks gestational age and/or below 1500 g). At 2 years corrected age, neurodevelopmental outcome was tested using Bayley's Scales of Infant Development-II, Lexilijst (lexical development questionnaire), and behavior checklists. Of 117 patients included, 85 experienced blood culture-proven infection. Coagulase-negative staphylococci were responsible for 55% of the episodes. No significant differences were found in cognitive, motor, and behavioral scores or lexiquotient comparing patients with versus no proven infection. When comparing three groups (coagulase-negative staphylococci, other, and negative blood culture), a significant difference was found in composite cognitive scores (p = 0.016), in favor of the coagulase-negative staphylococci group versus other causal agent group (p = 0.007). No significant differences were found in other subscales.Conclusion: In this cohort, no differences were found in neurodevelopmental outcome at 2 years corrected age between proven and no proven infection groups; confirmation in larger cohorts with a control group is needed. Patients encountering coagulase-negative staphylococci sepsis showed a significant better cognitive outcome compared to other causal agents.
KW - late-onset sepsis
KW - neonatal infection
KW - neurodevelopmental outcome
KW - preterm infant
KW - Late-onset sepsis
KW - Preterm infant
KW - NEONATAL INFECTION
KW - Neurodevelopmental outcome
U2 - 10.1007/s00431-019-03339-2
DO - 10.1007/s00431-019-03339-2
M3 - Article
SN - 0340-6199
VL - 178
SP - 673
EP - 680
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 5
ER -