Neurobiological factors modulating H1-antihistamine induced cognitive impairment

S. Conen

Research output: ThesisDoctoral ThesisInternal

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Some anti-allergy drugs (antihistamines) can cause fatigue. In the treatment of hay fever this fatigue is undesirable, because it can increase the risk of car accidents. But in the treatment of, for example, sleep disorders this fatigue may actually be desirable. This dissertation studied which mechanisms in the body make certain anti-allergy drugs cause fatigue. The research shows that genetic individual differences between people play a role in the degree of fatigue. The message of this dissertation is that these individual differences should be taken into account in medication treatments to guarantee the safety of treatments with among others antihistamines.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Ramaekers, Jan, Supervisor
  • Theunissen, Eef, Co-Supervisor
  • Vermeeren, Annemiek, Co-Supervisor
Award date23 Nov 2012
Place of PublicationMaastricht
Print ISBNs9789462031791
Publication statusPublished - 1 Jan 2012


  • Antihistamines
  • attention
  • healthy volunteers
  • MRI
  • EEC
  • driving studies
  • sedation/fatigue
  • cognition

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