Some anti-allergy drugs (antihistamines) can cause fatigue. In the treatment of hay fever this fatigue is undesirable, because it can increase the risk of car accidents. But in the treatment of, for example, sleep disorders this fatigue may actually be desirable. This dissertation studied which mechanisms in the body make certain anti-allergy drugs cause fatigue. The research shows that genetic individual differences between people play a role in the degree of fatigue. The message of this dissertation is that these individual differences should be taken into account in medication treatments to guarantee the safety of treatments with among others antihistamines.
|Qualification||Doctor of Philosophy|
|Award date||23 Nov 2012|
|Place of Publication||Maastricht|
|Publication status||Published - 1 Jan 2012|
- healthy volunteers
- driving studies