Neurobiological factors modulating H1-antihistamine induced cognitive impairment

S. Conen

doi:10.26481/dis.20121123sc

Neurobiological factors modulating H1-antihistamine induced cognitive impairment

S. Conen

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Some anti-allergy drugs (antihistamines) can cause fatigue. In the treatment of hay fever this fatigue is undesirable, because it can increase the risk of car accidents. But in the treatment of, for example, sleep disorders this fatigue may actually be desirable. This dissertation studied which mechanisms in the body make certain anti-allergy drugs cause fatigue. The research shows that genetic individual differences between people play a role in the degree of fatigue. The message of this dissertation is that these individual differences should be taken into account in medication treatments to guarantee the safety of treatments with among others antihistamines.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Ramaekers, Jan, Supervisor Theunissen, Eef, Co-Supervisor Vermeeren, Annemiek, Co-Supervisor
Award date	23 Nov 2012
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789462031791
DOIs	https://doi.org/10.26481/dis.20121123sc
Publication status	Published - 1 Jan 2012

Keywords

Antihistamines
attention
healthy volunteers
MRI
EEC
driving studies
sedation/fatigue
cognition

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10.26481/dis.20121123sc

Full TextFinal published version, 2.88 MB
CoverFinal published version, 609 KB
AbstractFinal published version, 123 KB
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Cite this

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KW - attention

KW - healthy volunteers

KW - MRI

KW - EEC

KW - driving studies

KW - sedation/fatigue

KW - cognition

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Neurobiological factors modulating H1-antihistamine induced cognitive impairment

Abstract

Keywords

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