Neuro-Cardiac-Guided TMS (NCG-TMS): Probing DLPFC-sgACC-vagus nerve connectivity using heart rate - First results

Tabitha A. Iseger; Frank Padberg; J. Leon Kenemans; Richard Gevirtz; Martijn Arns

doi:10.1016/j.brs.2017.05.002

Neuro-Cardiac-Guided TMS (NCG-TMS): Probing DLPFC-sgACC-vagus nerve connectivity using heart rate - First results

Tabitha A. Iseger^*, Frank Padberg, J. Leon Kenemans, Richard Gevirtz, Martijn Arns

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression.

Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system).

Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'.

Original language	English
Pages (from-to)	1006-1008
Number of pages	3
Journal	Brain stimulation
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.brs.2017.05.002
Publication status	Published - 2017
Externally published	Yes

Keywords

Vagus nerve
DLPFC
Heart rate
rTMS
Neuronavigation
Depression
TRANSCRANIAL MAGNETIC STIMULATION
DORSOLATERAL PREFRONTAL CORTEX
DEPRESSION
TARGETS

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10.1016/j.brs.2017.05.002

https://dspace.library.uu.nl/bitstream/handle/1874/359835/1_s2.0_S1935861X17307933_main.pdf?sequence=1&isAllowed=yLicence: Other

Cite this

@article{2d83d840038d40b6b97e46823ca1be16,

title = "Neuro-Cardiac-Guided TMS (NCG-TMS): Probing DLPFC-sgACC-vagus nerve connectivity using heart rate - First results",

abstract = "Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression.Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system).Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40\% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'.Conclusions: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network. (C) 2017 Elsevier Inc. All rights reserved.",

keywords = "Vagus nerve, DLPFC, Heart rate, rTMS, Neuronavigation, Depression, TRANSCRANIAL MAGNETIC STIMULATION, DORSOLATERAL PREFRONTAL CORTEX, DEPRESSION, TARGETS",

author = "Iseger, \{Tabitha A.\} and Frank Padberg and Kenemans, \{J. Leon\} and Richard Gevirtz and Martijn Arns",

year = "2017",

doi = "10.1016/j.brs.2017.05.002",

language = "English",

volume = "10",

pages = "1006--1008",

journal = "Brain stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Neuro-Cardiac-Guided TMS (NCG-TMS)

T2 - Probing DLPFC-sgACC-vagus nerve connectivity using heart rate - First results

AU - Iseger, Tabitha A.

AU - Padberg, Frank

AU - Kenemans, J. Leon

AU - Gevirtz, Richard

AU - Arns, Martijn

PY - 2017

Y1 - 2017

N2 - Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression.Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system).Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'.Conclusions: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network. (C) 2017 Elsevier Inc. All rights reserved.

AB - Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression.Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system).Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'.Conclusions: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network. (C) 2017 Elsevier Inc. All rights reserved.

KW - Vagus nerve

KW - DLPFC

KW - Heart rate

KW - rTMS

KW - Neuronavigation

KW - Depression

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - DORSOLATERAL PREFRONTAL CORTEX

KW - DEPRESSION

KW - TARGETS

U2 - 10.1016/j.brs.2017.05.002

DO - 10.1016/j.brs.2017.05.002

M3 - Article

C2 - 28545770

SN - 1935-861X

VL - 10

SP - 1006

EP - 1008

JO - Brain stimulation

JF - Brain stimulation

IS - 5

ER -

Neuro-Cardiac-Guided TMS (NCG-TMS): Probing DLPFC-sgACC-vagus nerve connectivity using heart rate - First results

Abstract

Keywords

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