Neuro-Cardiac-Guided TMS (NCG TMS): A replication and extension study

Tabitha A. Iseger, Frank Padberg, J. Leon Kenemans, Hanneke van Dijk, Martijn Arns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Web of Science)

Abstract

Neuro-Cardiac-Guided Transcranial Magnetic Stimulation (NCG-TMS) was studied for its potential to specifically target the frontal-vagal network. Previous research demonstrated that prefrontal stimulation led to significant heartrate slowing. We aimed to replicate these results in a larger sample and extend the findings to investigate dose-response relationships, reproducibility and stimulation frequency (10 Hz and intermittent theta burst (iTBS)). Data of forty-five healthy controls were analyzed, of which 28 received 10 Hz TMS (NCG-TMS) and 27 iTBS (NCG-iTBS; 10 received both protocols) at different stimulation sites according to the 10 20-EEG system. NCG-TMS yielded a relative heartrate deceleration at the F3/4 coil position replicating earlier studies. Both internal consistency and dose-response relationships were found. For NCG-iTBS adverse events were reported and topography for frontal-vagal activation was more lateralised relative to NCG-TMS. These results indicate that we were able to transsynaptically stimulate the frontal-vagal network and that excitability thresholds for the prefrontal cortex may differ relative to motor cortex.

Original languageEnglish
Article number108097
Number of pages11
JournalBiological Psychology
Volume162
DOIs
Publication statusPublished - May 2021

Keywords

  • TMS
  • Heart rate
  • Frontal-vagal
  • Dorsolateral prefrontal cortex
  • Target engagement
  • Personalized medicine
  • TRANSCRANIAL MAGNETIC STIMULATION
  • CORTICAL EXCITABILITY
  • PHOSPHENE THRESHOLDS
  • NERVE-STIMULATION
  • DEPRESSION
  • MOTOR
  • TARGETS
  • CONNECTIVITY
  • ASSOCIATION
  • DISORDER

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