Network topology of NaV1.7 mutations in sodium channel-related painful disorders

Dimos Kapetis*, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N. Xenakis, Ronald L. Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G. Faber, Monique Gerrits, Ingemar S. J. Merkies, Sulayman D. Dib-Hajj, Massimo Mantegazza, Stephen G. Waxman, PROPANE Study Grp, Hubertus J.M. Smeets, Giuseppe Lauria

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number28
Number of pages16
JournalBMC Systems Biology
Volume11
DOIs
Publication statusPublished - 24 Feb 2017

Keywords

  • Sodium channel
  • Neuropathic pain
  • Structural modeling
  • Network analysis
  • TRANSFER-RNA SYNTHETASE
  • MOLECULAR-DYNAMICS SIMULATIONS
  • OF-FUNCTION MUTATIONS
  • NA(V)1.7 MUTATION
  • PRIMARY ERYTHERMALGIA
  • ELECTROPHYSIOLOGICAL PROPERTIES
  • RESPONSIVE ERYTHROMELALGIA
  • NEURON HYPEREXCITABILITY
  • STRUCTURE PREDICTION
  • SLOW-INACTIVATION

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