Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma

Arnold-Jan Kruse; Brigitte Slangen; Gerard A. Dunselman; Tina Pirens; Frans C. H. Bakers; Jan P. A. Baak; Koen Van de Vijver

doi:10.1016/j.humpath.2010.08.017

Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma

Arnold-Jan Kruse^*, Brigitte Slangen, Gerard A. Dunselman, Tina Pirens, Frans C. H. Bakers, Jan P. A. Baak, Koen Van de Vijver

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for this tumor were the same as for their ovarian counterparts. This supports a mullerian origin and the current approach to extrapolate the results from ovarian mucinous cystadenocarcinoma trials in prescribing treatment for patients with extraovarian mucinous cystadenocarcinomas.

Original language	English
Pages (from-to)	743-748
Journal	Human Pathology
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.humpath.2010.08.017
Publication status	Published - May 2011

Keywords

Endocervicosis
Mucinous cystadenocarcinoma
KRAS
Extraovarian

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10.1016/j.humpath.2010.08.017

Cite this

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title = "Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma",

abstract = "Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for this tumor were the same as for their ovarian counterparts. This supports a mullerian origin and the current approach to extrapolate the results from ovarian mucinous cystadenocarcinoma trials in prescribing treatment for patients with extraovarian mucinous cystadenocarcinomas. ",

keywords = "Endocervicosis, Mucinous cystadenocarcinoma, KRAS, Extraovarian",

author = "Arnold-Jan Kruse and Brigitte Slangen and Dunselman, {Gerard A.} and Tina Pirens and Bakers, {Frans C. H.} and Baak, {Jan P. A.} and {Van de Vijver}, Koen",

year = "2011",

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AU - Kruse, Arnold-Jan

AU - Slangen, Brigitte

AU - Dunselman, Gerard A.

AU - Pirens, Tina

AU - Bakers, Frans C. H.

AU - Baak, Jan P. A.

AU - Van de Vijver, Koen

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AB - Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for this tumor were the same as for their ovarian counterparts. This supports a mullerian origin and the current approach to extrapolate the results from ovarian mucinous cystadenocarcinoma trials in prescribing treatment for patients with extraovarian mucinous cystadenocarcinomas.

KW - Endocervicosis

KW - Mucinous cystadenocarcinoma

KW - KRAS

KW - Extraovarian

U2 - 10.1016/j.humpath.2010.08.017

DO - 10.1016/j.humpath.2010.08.017

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