Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

Fritz Renner, Nicolette Siep, Arnoud Arntz, Vincent van de Ven, Frenk P M L Peeters, Conny W E M Quaedflieg, Marcus J H Huibers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).

METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.

RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.

LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.

CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

Original languageEnglish
Pages (from-to)590-596
Number of pages7
JournalJournal of Affective Disorders
Volume208
DOIs
Publication statusPublished - 15 Jan 2017

Cite this

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title = "Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression",
abstract = "BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.",
author = "Fritz Renner and Nicolette Siep and Arnoud Arntz and {van de Ven}, Vincent and Peeters, {Frenk P M L} and Quaedflieg, {Conny W E M} and Huibers, {Marcus J H}",
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year = "2017",
month = "1",
day = "15",
doi = "10.1016/j.jad.2016.10.022",
language = "English",
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Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression. / Renner, Fritz; Siep, Nicolette; Arntz, Arnoud; van de Ven, Vincent; Peeters, Frenk P M L; Quaedflieg, Conny W E M; Huibers, Marcus J H.

In: Journal of Affective Disorders, Vol. 208, 15.01.2017, p. 590-596.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression

AU - Renner, Fritz

AU - Siep, Nicolette

AU - Arntz, Arnoud

AU - van de Ven, Vincent

AU - Peeters, Frenk P M L

AU - Quaedflieg, Conny W E M

AU - Huibers, Marcus J H

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

AB - BACKGROUND: The aim of this study was to investigate the effects of sad mood on default mode network (DMN) resting-state connectivity in persons with chronic major depressive disorder (cMDD).METHODS: Participants with a diagnosis of cMDD (n=18) and age, gender and education level matched participants without a diagnosis of depression (n=18) underwent a resting-state fMRI scan, before and after a sad mood induction. The posterior cingulate cortex (PCC) was used as a seed for DMN functional connectivity across the two resting-state measurements.RESULTS: Mood ratings decreased in both groups following the sad mood induction procedure. PCC connectivity with the parahippocampal gyrus, the superior temporal gyrus and the anterior inferior temporal cortex increased in cMDD patients following the sad mood induction, whereas it decreased in non-patient controls. PCC connectivity with the anterior prefrontal cortex and the precuneus decreased in cMDD patients following the sad mood induction, whereas it increased in non-patient controls.LIMITATIONS: Limitations of this study include the relatively small sample size and lack of a clinical control group.CONCLUSIONS: These findings are in line with neurobiological models of depression suggesting that the observed changes in DMN connectivity following the sad mood induction might reflect a failure to exert cognitive control over negative memory retrieval in patients with cMDD.

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SN - 0165-0327

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