Negative (18)F-2-fluorodeoxyglucose PET/CT predicts good cancer specific survival in patients with a suspicion of recurrent ovarian cancer

C.B. Hebel, F.F. Behrendt, A. Heinzel, T. Krohn, F.M. Mottaghy, D.O. Bauerschlag, F.A. Verburg

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Abstract

AIM: The aim of the present study was to investigate the diagnostic and prognostic value of combined (18)F-2-fluorodeoxyglucose positron emission tomography and contrast enhanced X-ray computed tomography (FDG-PET/CT) in women with a suspicion of recurrent ovarian cancer. PATIENTS AND METHODS: We retrospectively reviewed 48 patients with a suspicion of recurrent ovarian cancer who were referred to our department for combined FDG-PET/CT. RESULTS: Median follow-up was 25 months. 38/48 (79%) patients showed pathological findings on PET/CT. 17/48 (35%) of patients died of ovarian cancer. One FDG-PET/CT was false positive and one was false negative, leading to a sensitivity and positive predictive value of 97% and a specificity and negative predictive value of 90%. 33/48 (69%) underwent a change in therapy following FDG-PET/CT. There was a significantly better survival in FDG-PET/CT negative than in positive patients (p=0.04). In the FDG-PET/CT negative group no patients had died of ovarian cancer during follow-up. Remarkably, there was no difference in survival between patients who only had peritoneal metastases on FDG-PET/CT and those who also had extraperitoneal metastases (p=0.71). CONCLUSION: A negative FDG-PET/CT has a high negative predictive value for the presence of disease and, more importantly, is associated with a very good disease-specific survival rate.
Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalEuropean Journal of Radiology
Volume83
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • FDG-PET/CT
  • Ovarian cancer
  • Prognosis
  • PET/CONTRAST-ENHANCED CT
  • DIAGNOSTIC-ACCURACY
  • F-18-FDG PET/CT
  • TOMOGRAPHY
  • MRI

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