Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Hendrik J. Niemarkt; Tim G. De Meij; Christ-jan van Ganzewinkel; Nanne K. H. de Boer; Peter Andriessen; Matthias C. Hutten; Boris W. Kramer

doi:10.1159/000497420

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Hendrik J. Niemarkt, Tim G. De Meij, Christ-jan van Ganzewinkel, Nanne K. H. de Boer, Peter Andriessen, Matthias C. Hutten, Boris W. Kramer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Web of Science)

Abstract

Necrotizing enterocolitis (NEC) is a relatively common disease in very-low-birth-weight infants and is associated with high mortality and morbidity. In survivors, neurodevelopmental impairment is frequently seen. The exact etiology remains largely to be elucidated, but microbiota are considered to play a major role in the development of NEC. Furthermore, emerging evidence exists that the microbiota is also of importance in brain function and development. Therefore, microbiota characterization has not only potential as a diagnostic or even preventive tool to predict NEC, but may also serve as a biomarker to monitor and possibly even as a target to manipulate brain development. Analysis of fecal volatile organic compounds, which shape the volatile metabolome and reflect microbiota function and host interaction, has been shown to be of interest in the diagnosis of NEC and late-onset sepsis. In this review, we discuss evidence of the role of the complex interplay between microbiota, NEC, and brain development, including the brain-gut axis in preterm infants. (c) 2019 The Author(s) Published by S. Karger AG, Basel

Original language	English
Pages (from-to)	423-431
Number of pages	9
Journal	Neonatology
Volume	115
Issue number	4
DOIs	https://doi.org/10.1159/000497420
Publication status	Published - 2019
Event	4th Meeting on Sharing Progress in Neonatology (SPIN) / 34th International Workshop on Surfactant Replacement - Parma, Italy Duration: 7 Jun 2019 → 8 Jun 2019

Keywords

Necrotizing enterocolitis
Brain development
Brain-gut axis
Preterm infants
VOLATILE ORGANIC-COMPOUNDS
BIRTH-WEIGHT INFANTS
NEURODEVELOPMENTAL OUTCOMES
INTESTINAL MICROBIOTA
PRETERM INFANTS
PAIN
PATHOGENESIS
COLONIZATION
RECOGNITION
INFECTION

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10.1159/000497420Licence: CC BY-NC-ND

Cite this

@article{ee13e1607747400d8212b410c9f49009,

title = "Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis",

abstract = "Necrotizing enterocolitis (NEC) is a relatively common disease in very-low-birth-weight infants and is associated with high mortality and morbidity. In survivors, neurodevelopmental impairment is frequently seen. The exact etiology remains largely to be elucidated, but microbiota are considered to play a major role in the development of NEC. Furthermore, emerging evidence exists that the microbiota is also of importance in brain function and development. Therefore, microbiota characterization has not only potential as a diagnostic or even preventive tool to predict NEC, but may also serve as a biomarker to monitor and possibly even as a target to manipulate brain development. Analysis of fecal volatile organic compounds, which shape the volatile metabolome and reflect microbiota function and host interaction, has been shown to be of interest in the diagnosis of NEC and late-onset sepsis. In this review, we discuss evidence of the role of the complex interplay between microbiota, NEC, and brain development, including the brain-gut axis in preterm infants. (c) 2019 The Author(s) Published by S. Karger AG, Basel",

keywords = "Necrotizing enterocolitis, Brain development, Brain-gut axis, Preterm infants, VOLATILE ORGANIC-COMPOUNDS, BIRTH-WEIGHT INFANTS, NEURODEVELOPMENTAL OUTCOMES, INTESTINAL MICROBIOTA, PRETERM INFANTS, PAIN, PATHOGENESIS, COLONIZATION, RECOGNITION, INFECTION",

author = "Niemarkt, {Hendrik J.} and {De Meij}, {Tim G.} and {van Ganzewinkel}, Christ-jan and {de Boer}, {Nanne K. H.} and Peter Andriessen and Hutten, {Matthias C.} and Kramer, {Boris W.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s) Published by S. Karger AG, Basel.; 4th Meeting on Sharing Progress in Neonatology (SPIN) / 34th International Workshop on Surfactant Replacement ; Conference date: 07-06-2019 Through 08-06-2019",

year = "2019",

doi = "10.1159/000497420",

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volume = "115",

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journal = "Neonatology",

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T2 - 4th Meeting on Sharing Progress in Neonatology (SPIN) / 34th International Workshop on Surfactant Replacement

AU - Niemarkt, Hendrik J.

AU - De Meij, Tim G.

AU - van Ganzewinkel, Christ-jan

AU - de Boer, Nanne K. H.

AU - Andriessen, Peter

AU - Hutten, Matthias C.

AU - Kramer, Boris W.

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N2 - Necrotizing enterocolitis (NEC) is a relatively common disease in very-low-birth-weight infants and is associated with high mortality and morbidity. In survivors, neurodevelopmental impairment is frequently seen. The exact etiology remains largely to be elucidated, but microbiota are considered to play a major role in the development of NEC. Furthermore, emerging evidence exists that the microbiota is also of importance in brain function and development. Therefore, microbiota characterization has not only potential as a diagnostic or even preventive tool to predict NEC, but may also serve as a biomarker to monitor and possibly even as a target to manipulate brain development. Analysis of fecal volatile organic compounds, which shape the volatile metabolome and reflect microbiota function and host interaction, has been shown to be of interest in the diagnosis of NEC and late-onset sepsis. In this review, we discuss evidence of the role of the complex interplay between microbiota, NEC, and brain development, including the brain-gut axis in preterm infants. (c) 2019 The Author(s) Published by S. Karger AG, Basel

AB - Necrotizing enterocolitis (NEC) is a relatively common disease in very-low-birth-weight infants and is associated with high mortality and morbidity. In survivors, neurodevelopmental impairment is frequently seen. The exact etiology remains largely to be elucidated, but microbiota are considered to play a major role in the development of NEC. Furthermore, emerging evidence exists that the microbiota is also of importance in brain function and development. Therefore, microbiota characterization has not only potential as a diagnostic or even preventive tool to predict NEC, but may also serve as a biomarker to monitor and possibly even as a target to manipulate brain development. Analysis of fecal volatile organic compounds, which shape the volatile metabolome and reflect microbiota function and host interaction, has been shown to be of interest in the diagnosis of NEC and late-onset sepsis. In this review, we discuss evidence of the role of the complex interplay between microbiota, NEC, and brain development, including the brain-gut axis in preterm infants. (c) 2019 The Author(s) Published by S. Karger AG, Basel

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KW - PRETERM INFANTS

KW - PAIN

KW - PATHOGENESIS

KW - COLONIZATION

KW - RECOGNITION

KW - INFECTION

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