Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study

Mahdi Al-Taher; Jacqueline van den Bos; Ivon Terink; Sander van Kuijk; Nehalennia van Hanegem; Nicole Bouvy; Marlies Bongers; Laurents Stassen; Arianne Lim

doi:10.3390/life12010015

Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study

Mahdi Al-Taher^*, Jacqueline van den Bos, Ivon Terink, Sander van Kuijk, Nehalennia van Hanegem, Nicole Bouvy, Marlies Bongers, Laurents Stassen, Arianne Lim

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy.

MATERIALS AND METHODS: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed.

RESULTS: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05).

CONCLUSION: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.

Original language	English
Number of pages	10
Journal	Life
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/life12010015
Publication status	Published - Jan 2022

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10.3390/life12010015Licence: CC BY

Cite this

@article{f292dcb5c19545a1971e35bc50700ab2,

title = "Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study",

abstract = "INTRODUCTION: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy.MATERIALS AND METHODS: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed.RESULTS: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05).CONCLUSION: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.",

author = "Mahdi Al-Taher and {van den Bos}, Jacqueline and Ivon Terink and {van Kuijk}, Sander and {van Hanegem}, Nehalennia and Nicole Bouvy and Marlies Bongers and Laurents Stassen and Arianne Lim",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/life12010015",

language = "English",

volume = "12",

journal = "Life",

issn = "2075-1729",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

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TY - JOUR

T1 - Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis

T2 - A Pilot Study

AU - Al-Taher, Mahdi

AU - van den Bos, Jacqueline

AU - Terink, Ivon

AU - van Kuijk, Sander

AU - van Hanegem, Nehalennia

AU - Bouvy, Nicole

AU - Bongers, Marlies

AU - Stassen, Laurents

AU - Lim, Arianne

PY - 2022/1

Y1 - 2022/1

N2 - INTRODUCTION: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy.MATERIALS AND METHODS: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed.RESULTS: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05).CONCLUSION: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.

AB - INTRODUCTION: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy.MATERIALS AND METHODS: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed.RESULTS: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05).CONCLUSION: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.

U2 - 10.3390/life12010015

DO - 10.3390/life12010015

M3 - Article

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